論文 - 詳細
| RRC ID | 663 |
|---|---|
| 著者 | Sasaki A, Itoh H, Gomi K, Ueguchi-Tanaka M, Ishiyama K, Kobayashi M, Jeong DH, An G, Kitano H, Ashikari M, Matsuoka M. |
| タイトル | Accumulation of phosphorylated repressor for gibberellin signaling in an F-box mutant. |
| ジャーナル | Science |
| Abstract |
Gibberellin (GA) regulates growth and development in plants. We isolated and characterized a rice GA-insensitive dwarf mutant, gid2. The GID2 gene encodes a putative F-box protein, which interacted with the rice Skp1 homolog in a yeast two-hybrid assay. In gid2, a repressor for GA signaling, SLR1, was highly accumulated in a phosphorylated form and GA increased its concentration, whereas SLR1 was rapidly degraded by GA through ubiquitination in the wild type. We conclude that GID2 is a positive regulator of GA signaling and that regulated degradation of SLR1 is initiated through GA-dependent phosphorylation and finalized by an SCF(GID2)-proteasome pathway. |
| 巻・号 | 299(5614) |
| ページ | 1896-8 |
| 公開日 | 2003-3-21 |
| DOI | 10.1126/science.1081077 |
| PII | 299/5614/1896 |
| PMID | 12649483 |
| MeSH | Alleles Amino Acid Sequence Codon, Terminator Enzyme Induction Genes, Plant Gibberellins / metabolism* Gibberellins / pharmacology Ligases / metabolism Molecular Sequence Data Mutation Open Reading Frames Oryza / genetics Oryza / growth & development Oryza / metabolism* Peptide Hydrolases / metabolism Phenotype Phosphorylation Plant Proteins / chemistry Plant Proteins / genetics* Plant Proteins / metabolism* Proteasome Endopeptidase Complex* Protein Structure, Tertiary Seeds / metabolism Signal Transduction* Ubiquitin / metabolism Ubiquitin-Protein Ligases alpha-Amylases / biosynthesis |
| IF | 41.846 |
| 引用数 | 405 |
| WOS 分野 | PLANT SCIENCES |
| リソース情報 | |
| イネ | Dwarf Mutant |