論文 - 詳細
| RRC ID | 6666 |
|---|---|
| 著者 | Li G, Foote C, Alexander S, Alexander H. |
| タイトル | Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum. |
| ジャーナル | Development |
| Abstract |
Sphingosine-1-phosphate, a product of sphingomyelin degradation, is an important element of signal transduction pathways that regulate cell proliferation and cell death. We have demonstrated additional roles for sphingosine-1-phosphate in growth and multicellular development. The specific disruption in Dictyostelium discoideum of the sphingosine-1-phosphate lyase gene, which encodes the enzyme that catalyzes sphingosine-1-phosphate degradation, results in a mutant strain with aberrant morphogenesis, as well as an increase in viability during stationary phase. The absence of sphingosine-1-phosphate lyase affects multiple stages throughout development, including the cytoskeletal architecture of aggregating cells, the ability to form migrating slugs, and the control of cell type-specific gene expression and terminal spore differentiation. This pleiotropic effect, which is due to the loss of sphingosine-1-phosphate lyase, establishes sphingolipids as pivotal regulatory molecules in a wide range of processes in multicellular development. |
| 巻・号 | 128(18) |
| ページ | 3473-83 |
| 公開日 | 2001-9-1 |
| DOI | 10.1242/dev.128.18.3473 |
| PMID | 11566853 |
| MeSH | Actins / isolation & purification Aldehyde-Lyases / genetics Aldehyde-Lyases / metabolism* Amino Acid Sequence Animals Cytoskeleton / physiology Dictyostelium / enzymology Dictyostelium / genetics Dictyostelium / growth & development* Genes, Protozoan Lysophospholipids* Molecular Sequence Data Morphogenesis Movement Mutagenesis, Site-Directed Mutation Pseudopodia / genetics Sequence Homology, Amino Acid Sphingosine / analogs & derivatives* Sphingosine / metabolism* |
| IF | 5.611 |
| 引用数 | 62 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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