RRC ID 6666
著者 Li G, Foote C, Alexander S, Alexander H.
タイトル Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum.
ジャーナル Development
Abstract Sphingosine-1-phosphate, a product of sphingomyelin degradation, is an important element of signal transduction pathways that regulate cell proliferation and cell death. We have demonstrated additional roles for sphingosine-1-phosphate in growth and multicellular development. The specific disruption in Dictyostelium discoideum of the sphingosine-1-phosphate lyase gene, which encodes the enzyme that catalyzes sphingosine-1-phosphate degradation, results in a mutant strain with aberrant morphogenesis, as well as an increase in viability during stationary phase. The absence of sphingosine-1-phosphate lyase affects multiple stages throughout development, including the cytoskeletal architecture of aggregating cells, the ability to form migrating slugs, and the control of cell type-specific gene expression and terminal spore differentiation. This pleiotropic effect, which is due to the loss of sphingosine-1-phosphate lyase, establishes sphingolipids as pivotal regulatory molecules in a wide range of processes in multicellular development.
巻・号 128(18)
ページ 3473-83
公開日 2001-9-1
DOI 10.1242/dev.128.18.3473
PMID 11566853
MeSH Actins / isolation & purification Aldehyde-Lyases / genetics Aldehyde-Lyases / metabolism* Amino Acid Sequence Animals Cytoskeleton / physiology Dictyostelium / enzymology Dictyostelium / genetics Dictyostelium / growth & development* Genes, Protozoan Lysophospholipids* Molecular Sequence Data Morphogenesis Movement Mutagenesis, Site-Directed Mutation Pseudopodia / genetics Sequence Homology, Amino Acid Sphingosine / analogs & derivatives* Sphingosine / metabolism*
IF 5.611
引用数 62
WOS 分野 DEVELOPMENTAL BIOLOGY
リソース情報
細胞性粘菌