論文 - 詳細
| RRC ID | 67028 |
|---|---|
| 著者 | Zhou H, Ji J, Chen X, Bi Y, Li J, Wang Q, Hu T, Song H, Zhao R, Chen Y, Cui M, Zhang Y, Hughes AC, Holmes EC, Shi W. |
| タイトル | Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses. |
| ジャーナル | Cell |
| Abstract |
Despite the discovery of animal coronaviruses related to SARS-CoV-2, the evolutionary origins of this virus are elusive. We describe a meta-transcriptomic study of 411 bat samples collected from a small geographical region in Yunnan province, China, between May 2019 and November 2020. We identified 24 full-length coronavirus genomes, including four novel SARS-CoV-2-related and three SARS-CoV-related viruses. Rhinolophus pusillus virus RpYN06 was the closest relative of SARS-CoV-2 in most of the genome, although it possessed a more divergent spike gene. The other three SARS-CoV-2-related coronaviruses carried a genetically distinct spike gene that could weakly bind to the hACE2 receptor in vitro. Ecological modeling predicted the co-existence of up to 23 Rhinolophus bat species, with the largest contiguous hotspots extending from South Laos and Vietnam to southern China. Our study highlights the remarkable diversity of bat coronaviruses at the local scale, including close relatives of both SARS-CoV-2 and SARS-CoV. |
| 巻・号 | 184(17) |
| ページ | 4380-4391.e14 |
| 公開日 | 2021-8-19 |
| DOI | 10.1016/j.cell.2021.06.008 |
| PII | S0092-8674(21)00709-1 |
| PMID | 34147139 |
| PMC | PMC8188299 |
| MeSH | Amino Acid Sequence Angiotensin-Converting Enzyme 2 / chemistry Angiotensin-Converting Enzyme 2 / metabolism Animals Asia, Southeastern COVID-19 / virology* China Chiroptera / virology* Coronavirus / classification Coronavirus / genetics* Coronavirus / isolation & purification Ecological and Environmental Phenomena Evolution, Molecular* Genome, Viral Humans Models, Molecular Phylogeny SARS-CoV-2 / genetics* SARS-CoV-2 / physiology Sequence Alignment Sequence Analysis, RNA Spike Glycoprotein, Coronavirus / chemistry Spike Glycoprotein, Coronavirus / genetics Spike Glycoprotein, Coronavirus / metabolism Viral Zoonoses |
| IF | 38.637 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1480 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 7.7 |
| リソース情報 | |
| GBIF | Mammal specimens of Takatsuki Nature Museum (Aquapia Akutagawa) |