| RRC ID |
67668
|
| Author |
Chiba S, Ikushima H, Ueki H, Yanai H, Kimura Y, Hangai S, Nishio J, Negishi H, Tamura T, Saijo S, Iwakura Y, Taniguchi T.
|
| Title |
Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses.
|
| Journal |
Elife
|
| Abstract |
The eradication of tumor cells requires communication to and signaling by cells of the immune system. Natural killer (NK) cells are essential tumor-killing effector cells of the innate immune system; however, little is known about whether or how other immune cells recognize tumor cells to assist NK cells. Here, we show that the innate immune receptor Dectin-1 expressed on dendritic cells and macrophages is critical to NK-mediated killing of tumor cells that express N-glycan structures at high levels. Receptor recognition of these tumor cells causes the activation of the IRF5 transcription factor and downstream gene induction for the full-blown tumoricidal activity of NK cells. Consistent with this, we show exacerbated in vivo tumor growth in mice genetically deficient in either Dectin-1 or IRF5. The critical contribution of Dectin-1 in the recognition of and signaling by tumor cells may offer new insight into the anti-tumor immune system with therapeutic implications.
|
| Volume |
3
|
| Pages |
e04177
|
| Published |
2014-8-22
|
| DOI |
10.7554/eLife.04177
|
| PMID |
25149452
|
| PMC |
PMC4161974
|
| MeSH |
Animals
Cell Communication
Cell Line, Tumor
Cell Proliferation
Cytotoxicity, Immunologic
Dendritic Cells / metabolism
Gene Expression Regulation, Neoplastic
HEK293 Cells
Humans
Immunity, Innate / immunology*
Interferon Regulatory Factors / metabolism
Killer Cells, Natural / immunology
Lectins, C-Type / deficiency
Lectins, C-Type / metabolism*
Macrophages / metabolism
Melanoma, Experimental / genetics
Melanoma, Experimental / immunology*
Melanoma, Experimental / pathology*
Mice, Inbred C57BL
Models, Immunological
Polysaccharides / chemistry
Polysaccharides / metabolism
Protein Binding
RNA, Messenger / genetics
RNA, Messenger / metabolism
Signal Transduction / immunology
|
| IF |
7.08
|
| Resource |
| DNA material |
CSII-EF-MCS-IRES2-Venus (RDB04384)
pCMV-VSV-G-RSV-Rev (RDB04393) |
| Human and Animal Cells |
HeLa
A549(RCB0098)
HCT116(RCB2979)
MKN45(RCB1001)
PC-3(RCB2145)
K562(RCB1897)
B16F1(RCB2649)
B16F10(RCB2630)
LLC(RCB0558)
293T(RCB2202) |
