論文 - 詳細
| RRC ID | 67668 |
|---|---|
| 著者 | Chiba S, Ikushima H, Ueki H, Yanai H, Kimura Y, Hangai S, Nishio J, Negishi H, Tamura T, Saijo S, Iwakura Y, Taniguchi T. |
| タイトル | Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses. |
| ジャーナル | Elife |
| Abstract |
The eradication of tumor cells requires communication to and signaling by cells of the immune system. Natural killer (NK) cells are essential tumor-killing effector cells of the innate immune system; however, little is known about whether or how other immune cells recognize tumor cells to assist NK cells. Here, we show that the innate immune receptor Dectin-1 expressed on dendritic cells and macrophages is critical to NK-mediated killing of tumor cells that express N-glycan structures at high levels. Receptor recognition of these tumor cells causes the activation of the IRF5 transcription factor and downstream gene induction for the full-blown tumoricidal activity of NK cells. Consistent with this, we show exacerbated in vivo tumor growth in mice genetically deficient in either Dectin-1 or IRF5. The critical contribution of Dectin-1 in the recognition of and signaling by tumor cells may offer new insight into the anti-tumor immune system with therapeutic implications. |
| 巻・号 | 3 |
| ページ | e04177 |
| 公開日 | 2014-8-22 |
| DOI | 10.7554/eLife.04177 |
| PMID | 25149452 |
| PMC | PMC4161974 |
| MeSH | Animals Cell Communication Cell Line, Tumor Cell Proliferation Cytotoxicity, Immunologic Dendritic Cells / metabolism Gene Expression Regulation, Neoplastic HEK293 Cells Humans Immunity, Innate / immunology* Interferon Regulatory Factors / metabolism Killer Cells, Natural / immunology Lectins, C-Type / deficiency Lectins, C-Type / metabolism* Macrophages / metabolism Melanoma, Experimental / genetics Melanoma, Experimental / immunology* Melanoma, Experimental / pathology* Mice, Inbred C57BL Models, Immunological Polysaccharides / chemistry Polysaccharides / metabolism Protein Binding RNA, Messenger / genetics RNA, Messenger / metabolism Signal Transduction / immunology |
| IF | 7.08 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 12 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | CSII-EF-MCS-IRES2-Venus (RDB04384) pCMV-VSV-G-RSV-Rev (RDB04393) |
| ヒト・動物細胞 | HeLa A549(RCB0098) HCT116(RCB2979) MKN45(RCB1001) PC-3(RCB2145) K562(RCB1897) B16F1(RCB2649) B16F10(RCB2630) LLC(RCB0558) 293T(RCB2202) |