RRC ID 67816
著者 Ishikawa S, Nishida N, Fujino S, Ogino T, Takahashi H, Miyoshi N, Uemura M, Satoh T, Yamamoto H, Mizushima T, Doki Y, Eguchi H.
タイトル Comprehensive profiling of novel epithelial-mesenchymal transition mediators and their clinical significance in colorectal cancer.
ジャーナル Sci Rep
Abstract Epithelial-mesenchymal transition (EMT) is a drastic phenotypic change during cancer metastasis and is one of the most important hallmarks of aggressive cancer. Although the overexpression of some specific transcription factors explains the functional alteration of EMT-induced cells, a complete picture of this biological process is yet to be elucidated. To comprehensively profile EMT-related genes in colorectal cancer, we quantified the EMT induction ability of each gene according to its similarity to the cancer stromal gene signature and termed it "mesenchymal score." This bioinformatic approach successfully identified 90 candidate EMT mediators, which are strongly predictive of survival in clinical samples. Among these candidates, we discovered that the neuronal gene ARC, possibly originating from the retrotransposon, unexpectedly plays a crucial role in EMT induction. Profiling of novel EMT mediators we demonstrated here may help understand the complexity of the EMT program and open up new avenues for therapeutic intervention in colorectal cancer.
巻・号 11(1)
ページ 11759
公開日 2021-6-3
DOI 10.1038/s41598-021-91102-9
PII 10.1038/s41598-021-91102-9
PMID 34083586
PMC PMC8175715
MeSH Aged Aged, 80 and over Biomarkers, Tumor* Cell Line, Tumor Cell Movement / genetics Cell Proliferation / genetics Colorectal Neoplasms / etiology* Colorectal Neoplasms / metabolism Colorectal Neoplasms / pathology* Computational Biology / methods Epithelial-Mesenchymal Transition* / genetics Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Immunophenotyping Male Middle Aged Molecular Sequence Annotation Reproducibility of Results Transcriptome Transforming Growth Factor beta / metabolism
IF 3.998
リソース情報
遺伝子材料 CSII-CMV-MCS-IRES2-Bsd (RDB04385)