論文 - 詳細
| RRC ID | 6804 |
|---|---|
| 著者 | Nishiyama N, Nakagishi Y, Morimoto Y, Lai PS, Miyazaki K, Urano K, Horie S, Kumagai M, Fukushima S, Cheng Y, Jang WD, Kikuchi M, Kataoka K. |
| タイトル | Enhanced photodynamic cancer treatment by supramolecular nanocarriers charged with dendrimer phthalocyanine. |
| ジャーナル | J Control Release |
| Abstract |
Photodynamic therapy (PDT) is a promising method for the localized treatment of solid tumors. In order to enhance the efficacy of PDT, we have recently developed a novel class of photosensitizer formulation, i.e., the dendrimer phthalocyanine (DPc)-encapsulated polymeric micelle (DPc/m). The DPc/m induced efficient and unprecedentedly rapid cell death accompanied by characteristic morphological changes such as blebbing of cell membranes, when the cells were photoirradiated using a low power halogen lamp or a high power diode laser. The fluorescent microscopic observation using organelle-specific dyes demonstrated that DPc/m might accumulate in the endo-/lysosomes; however, upon photoirradiation, DPc/m might be promptly released into the cytoplasm and photodamage the mitochondria, which may account for the enhanced photocytotoxicity of DPc/m. This study also demonstrated that DPc/m showed significantly higher in vivo PDT efficacy than clinically used Photofrin (polyhematoporphyrin esters, PHE) in mice bearing human lung adenocarcinoma A549 cells. Furthermore, the DPc/m-treated mice did not show skin phototoxiciy, which was apparently observed for the PHE-treated mice, under the tested conditions. These results strongly suggest the usefulness of DPc/m in clinical PDT. |
| 巻・号 | 133(3) |
| ページ | 245-51 |
| 公開日 | 2009-2-10 |
| DOI | 10.1016/j.jconrel.2008.10.010 |
| PII | S0168-3659(08)00634-2 |
| PMID | 19000725 |
| MeSH | Animals Cell Line, Tumor Cell Survival / drug effects Cell Survival / radiation effects Dendrimers / chemistry* Dihematoporphyrin Ether / administration & dosage Dihematoporphyrin Ether / chemistry Dihematoporphyrin Ether / therapeutic use Drug Delivery Systems / methods* Female Humans Indoles / administration & dosage* Indoles / chemistry Indoles / therapeutic use Isoindoles Lasers Liver / drug effects Liver / pathology Mice Mice, Inbred BALB C Micelles Nanoparticles Neoplasms / drug therapy* Neoplasms / metabolism Neoplasms / pathology Photochemotherapy / adverse effects Photochemotherapy / methods* Polyethylene Glycols / chemistry Polylysine / chemistry Radiation-Sensitizing Agents / administration & dosage Radiation-Sensitizing Agents / chemistry Radiation-Sensitizing Agents / therapeutic use Reactive Oxygen Species / metabolism Skin / drug effects Skin / pathology Xenograft Model Antitumor Assays |
| IF | 7.727 |
| 引用数 | 112 |
| WOS 分野 | PHARMACOLOGY & PHARMACY CHEMISTRY, MULTIDISCIPLINARY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | A549(RCB0098) |