論文 - 詳細
| RRC ID | 6828 |
|---|---|
| 著者 | Veeranarayanan S, Poulose AC, Mohamed MS, Varghese SH, Nagaoka Y, Yoshida Y, Maekawa T, Kumar DS. |
| タイトル | Synergistic targeting of cancer and associated angiogenesis using triple-targeted dual-drug silica nanoformulations for theragnostics. |
| ジャーナル | Small |
| Abstract |
The targeting and therapeutic efficacy of dye- and dual-drug-loaded silica nanoparticles, functionalized with triple targeting ligands specific towards cancer and neoangiogenesis simultaneously, are discussed. This synergized, high-precision, multitarget concept culminates in an elevated uptake of nanoparticles by cancer and angiogenic cells with amplified proficiency, thereby imparting superior therapeutic efficacy against breast cancer cells and completely disabling the migration and angiogenic sprouting ability of activated endothelial cells. The exceptional multimodal efficiency achieved by this single therapeutic nanoformulation holds promise for the synergistic targeting and treatment of the yet elusive cancer and its related angiogenesis in a single, lethal shot. |
| 巻・号 | 8(22) |
| ページ | 3476-89 |
| 公開日 | 2012-11-19 |
| DOI | 10.1002/smll.201200874 |
| PMID | 22865683 |
| MeSH | Angiogenesis Inhibitors / chemistry Animals Breast Neoplasms / drug therapy Cell Line Cell Proliferation / drug effects Cetrimonium Cetrimonium Compounds / chemistry Drug Delivery Systems Drug Synergism Endothelial Cells / drug effects Female Fluorescent Dyes / chemistry Human Umbilical Vein Endothelial Cells Humans Ligands Lipids / chemistry MCF-7 Cells Mice Microscopy, Electron, Transmission Microscopy, Fluorescence Nanomedicine / methods* Nanoparticles Neoplasms / therapy* Neovascularization, Pathologic* Polyethylene Glycols / chemistry Silicon Dioxide / chemistry |
| IF | 5.145 |
| 引用数 | 236 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MCF7(RCB1904) L929 |