| RRC ID |
68930
|
| Author |
Akao Y, Kuranaga Y, Heishima K, Sugito N, Morikawa K, Ito Y, Soga T, Ito T.
|
| Title |
Plant hvu-MIR168-3p enhances expression of glucose transporter 1 (SLC2A1) in human cells by silencing genes related to mitochondrial electron transport chain complex I.
|
| Journal |
J Nutr Biochem
|
| Abstract |
Diet is a crucial factor for preventing most diseases. Edible plant extracts are known to contain exosome-like nanoparticles, in which food-derived plant microRNAs are included and may serve as a novel functional component in human health. Here, we demonstrated that hvu-MIR168-3p included in the nanoparticles of rice aleurone cells down-regulated the expression of the genes related to mitochondrial electron transport chain complex I in human cells. Subsequently, hvu-MIR168-3p enhanced protein and RNA expression levels of glucose transporter I and caused a decrease in the blood glucose level, which findings were obtained by in vitro and in vivo experiments, respectively. These findings suggest that a cross-kingdom relationship between plants and humans with respect to hvu-MIR168-3p exists and may contribute to preventive medicine for GLUT1-related dysfunctions including glucose metabolism, aging, and tumor immunology.
|
| Volume |
101
|
| Pages |
108922
|
| Published |
2022-3-1
|
| DOI |
10.1016/j.jnutbio.2021.108922
|
| PII |
S0955-2863(21)00342-9
|
| PMID |
34856354
|
| MeSH |
Animals
Blood Glucose / analysis
Cell Line, Tumor
Cell Proliferation
Down-Regulation
Electron Transport Complex I / genetics*
Enterocytes / metabolism
Gene Expression
Glucose Transporter Type 1 / genetics
Glucose Transporter Type 1 / metabolism*
Humans
Male
Metabolome
Mice
Mice, Inbred ICR
MicroRNAs / genetics*
Mitochondria / metabolism
Nanoparticles
Oryza / genetics*
Oxidative Phosphorylation
RNA Interference*
RNA, Plant / genetics*
Rats
Up-Regulation
|
| IF |
4.873
|
| Resource |
| Human and Animal Cells |
IEC 6(RCB0993) |
