Reference - Detail
| RRC ID | 68930 |
|---|---|
| Author | Akao Y, Kuranaga Y, Heishima K, Sugito N, Morikawa K, Ito Y, Soga T, Ito T. |
| Title | Plant hvu-MIR168-3p enhances expression of glucose transporter 1 (SLC2A1) in human cells by silencing genes related to mitochondrial electron transport chain complex I. |
| Journal | J Nutr Biochem |
| Abstract |
Diet is a crucial factor for preventing most diseases. Edible plant extracts are known to contain exosome-like nanoparticles, in which food-derived plant microRNAs are included and may serve as a novel functional component in human health. Here, we demonstrated that hvu-MIR168-3p included in the nanoparticles of rice aleurone cells down-regulated the expression of the genes related to mitochondrial electron transport chain complex I in human cells. Subsequently, hvu-MIR168-3p enhanced protein and RNA expression levels of glucose transporter I and caused a decrease in the blood glucose level, which findings were obtained by in vitro and in vivo experiments, respectively. These findings suggest that a cross-kingdom relationship between plants and humans with respect to hvu-MIR168-3p exists and may contribute to preventive medicine for GLUT1-related dysfunctions including glucose metabolism, aging, and tumor immunology. |
| Volume | 101 |
| Pages | 108922 |
| Published | 2022-3-1 |
| DOI | 10.1016/j.jnutbio.2021.108922 |
| PII | S0955-2863(21)00342-9 |
| PMID | 34856354 |
| MeSH | Animals Blood Glucose / analysis Cell Line, Tumor Cell Proliferation Down-Regulation Electron Transport Complex I / genetics* Enterocytes / metabolism Gene Expression Glucose Transporter Type 1 / genetics Glucose Transporter Type 1 / metabolism* Humans Male Metabolome Mice Mice, Inbred ICR MicroRNAs / genetics* Mitochondria / metabolism Nanoparticles Oryza / genetics* Oxidative Phosphorylation RNA Interference* RNA, Plant / genetics* Rats Up-Regulation |
| IF | 4.873 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | IEC 6(RCB0993) |