論文 - 詳細
| RRC ID | 68970 |
|---|---|
| 著者 | Ohtsuka H, Kobayashi M, Shimasaki T, Sato T, Akanuma G, Kitaura Y, Otsubo Y, Yamashita A, Aiba H. |
| タイトル | Magnesium depletion extends fission yeast lifespan via general amino acid control activation. |
| ジャーナル | Microbiologyopen |
| Abstract |
Nutrients including glucose, nitrogen, sulfur, zinc, and iron are involved in the regulation of chronological lifespan (CLS) of yeast, which serves as a model of the lifespan of differentiated cells of higher organisms. Herein, we show that magnesium (Mg2+ ) depletion extends CLS of the fission yeast Schizosaccharomyces pombe through a mechanism involving the Ecl1 gene family. We discovered that ecl1+ expression, which extends CLS, responds to Mg2+ depletion. Therefore, we investigated the underlying intracellular responses. In amino acid auxotrophic strains, Mg2+ depletion robustly induces ecl1+ expression through the activation of the general amino acid control (GAAC) pathway-the equivalent of the amino acid response of mammals. Polysome analysis indicated that the expression of Ecl1 family genes was required for regulating ribosome amount when cells were starved, suggesting that Ecl1 family gene products control the abundance of ribosomes, which contributes to longevity through the activation of the evolutionarily conserved GAAC pathway. The present study extends our understanding of the cellular response to Mg2+ depletion and its influence on the mechanism controlling longevity. |
| 巻・号 | 10(2) |
| ページ | e1176 |
| 公開日 | 2021-3-1 |
| DOI | 10.1002/mbo3.1176 |
| PMID | 33970532 |
| PMC | PMC8088111 |
| MeSH | Amino Acids / metabolism* Cell Cycle Gene Expression Regulation, Fungal Genes, Fungal Longevity Magnesium / metabolism* Nuclear Proteins / physiology* Nutrients / metabolism Ribosomes / metabolism* Schizosaccharomyces / physiology* Schizosaccharomyces pombe Proteins / physiology* |
| IF | 3.142 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 酵母 | FY10704 FY7876 |