論文 - 詳細
| RRC ID | 69056 |
|---|---|
| 著者 | Yasuda Y, Nagano T, Jimbo N, Kiriu T, Suraya R, Hazama D, Yamamoto M, Maniwa Y, Nishimura Y, Kobayashi K. |
| タイトル | Chloride Intracellular Channel 1 Expression Is Associated With Poor Prognosis of Lung Adenocarcinoma. |
| ジャーナル | Anticancer Res |
| Abstract |
BACKGROUND/AIM:Chloride intracellular channel 1 (CLIC1) is a member of the chloride channel protein family. The aim of this study was to clarify the role of CLIC1 in lung adenocarcinoma. PATIENTS AND METHODS:The expression levels of CLIC1 in 74 patients with completely resected lung adenocarcinoma were analyzed by immunohistochemistry. Overall survival was assessed in relation to the expression level of CLIC1. Moreover, in the lung cancer cell lines A549 and PC9, CLIC1 expression was inhibited by small interfering RNA. The function of CLIC1 was analyzed in these cell lines. RESULTS:High expression of CLIC1 was associated with short overall survival compared to low expression (p=0.0327). Multivariate analysis revealed that CLIC1 expression was an independent prognostic factor. Knockdown of CLIC1 inhibited cell proliferation and migration through suppression of the p38 MAPK signaling pathway in A549 and PC9 cells. CONCLUSION:CLIC1 may be a useful prognostic factor in lung adenocarcinoma. |
| 巻・号 | 42(1) |
| ページ | 271-277 |
| 公開日 | 2022-1-1 |
| DOI | 10.21873/anticanres.15482 |
| PII | 42/1/271 |
| PMID | 34969734 |
| MeSH | A549 Cells Adenocarcinoma of Lung / genetics* Adenocarcinoma of Lung / pathology Aged Aged, 80 and over Cell Movement / genetics Cell Proliferation / genetics* Chloride Channels / genetics* Female Gene Expression Regulation, Neoplastic / genetics Humans Male Prognosis RNA, Small Interfering / genetics Signal Transduction / genetics |
| IF | 1.994 |
| リソース情報 | |
| ヒト・動物細胞 | II-18(RCB2093) |