RRC ID 69137
Author Sun Y, Li Z, Li W, Xue L.
Title Loss of Bicra impairs Drosophila learning and choice abilities.
Journal Neurosci Lett
Abstract The Drosophila Bicra (CG11873) gene encodes the sole ortholog of mammalian GLTSCR1 and GLTSCR1L, which are components of a chromatin remodeling complex involved in neoplasia and metastasis of cancer cells. Bicra is highly expressed in Drosophila larval CNS and adult brain, yet its physiological functions in the nervous system remain elusive. Here we report that Bicra is expressed in both neurons and glia of adult brains, and is required for courtship learning and choice ability of male flies. The function of Bicra in the mushroom body, and in particular, Bicra expression in neurons but not glia, is responsible for the male courtship learning and choice performance. This study unravels a novel function of Bicra in cognition-related courtship behaviors in Drosophila, and may provide insight into the neuronal functions of its mammalian orthologs.
Volume 769
Pages 136432
Published 2021-12-30
DOI 10.1016/j.neulet.2021.136432
PII S0304-3940(21)00811-9
PMID 34974109
IF 2.173