Reference - Detail
| RRC ID | 69470 |
|---|---|
| Author | Kinoshita H, Shimozato O, Ishii T, Kamoda H, Hagiwara Y, Tsukanishi T, Ohtori S, Yonemoto T. |
| Title | The Thioredoxin Reductase Inhibitor Auranofin Suppresses Pulmonary Metastasis of Osteosarcoma, But Not Local Progression. |
| Journal | Anticancer Res |
| Abstract |
BACKGROUND/AIM:Auranofin (AUR), a thioredoxin reductase (TXNRD) inhibitor, shows anticancer activity against several cancers. This study investigated the effects of AUR on the local progression and pulmonary metastasis of osteosarcoma (OS). MATERIALS AND METHODS:Publicly available expression cohorts were analysed to study the relationship between TXNRD-2 expression and the survival of patients with OS. The murine OS cell line LM8 was stimulated with AUR. Cell viability, apoptosis-related protein levels, caspase activity, and wound healing were analysed. Tumor progression and pulmonary metastasis were investigated in C3H mice implanted with LM8 cells. RESULTS:High-level expression of TXNRD-2 represented a negative prognostic factor for metastasis and overall survival in patients with OS. AUR induced apoptosis of OS cells via the oxidative stress-MAPK-Caspase 3 pathway, and suppressed the migration of OS cells. AUR inhibited the pulmonary metastasis of OS, but not local progression. CONCLUSION:AUR represents a potential therapeutic drug for suppressing pulmonary metastasis of OS. |
| Volume | 41(10) |
| Pages | 4947-4955 |
| Published | 2021-10-1 |
| DOI | 10.21873/anticanres.15308 |
| PII | 41/10/4947 |
| PMID | 34593442 |
| MeSH | Animals Antirheumatic Agents / pharmacology Apoptosis Auranofin / pharmacology* Bone Neoplasms / drug therapy* Bone Neoplasms / metabolism Bone Neoplasms / pathology Cell Movement Cell Proliferation Female Humans Lung Neoplasms / drug therapy* Lung Neoplasms / metabolism Lung Neoplasms / secondary Mice Mice, Inbred C3H Osteosarcoma / drug therapy* Osteosarcoma / metabolism Osteosarcoma / pathology Prognosis Survival Rate Thioredoxin-Disulfide Reductase / antagonists & inhibitors* Tumor Cells, Cultured Xenograft Model Antitumor Assays |
| IF | 1.994 |
| Resource | |
| Human and Animal Cells | LM8(RCB1450) |