| RRC ID |
70074
|
| Author |
Kasai A, Jee E, Tamura Y, Kouzaki K, Kotani T, Nakazato K.
|
| Title |
Aldehyde dehydrogenase 2 deficiency promotes skeletal muscle atrophy in aged mice.
|
| Journal |
Am J Physiol Regul Integr Comp Physiol
|
| Abstract |
Aldehyde dehydrogenase 2 (ALDH2) detoxifies acetaldehyde produced from ethanol. A missense single nucleotide polymorphism (SNP) rs671 in ALDH2 exhibits a dominant-negative form of the ALDH2 protein. Nearly 40% of people in East Asia carry an inactive ALDH2*2 mutation. Previous studies reported that ALDH2*2 is associated with increased risk of several diseases. In this study, we examined the effect of ALDH2 deficiency on age-related muscle atrophy and its underlying mechanisms. We found that ALDH2 deficiency promotes age-related loss of muscle fiber cross-sectional areas, especially in oxidative fibers. Furthermore, ALDH2 deficiency exacerbated age-related accumulation of 4-hydroxy-2-nonenal (4-HNE), a marker of oxidative stress in the gastrocnemius muscle. Similarly, mitochondrial reactive oxygen species (ROS) production increased in aged ALDH2-knockout mice, indicating that ALDH2 deficiency induced mitochondrial dysfunction. In summary, ALDH2 deficiency promotes age-related muscle loss, especially in oxidative fibers, which may be associated with an increased accumulation of oxidative stress via mitochondrial dysfunction.
|
| Volume |
322(6)
|
| Pages |
R511-R525
|
| Published |
2022-6-1
|
| DOI |
10.1152/ajpregu.00304.2021
|
| PMID |
35318866
|
| MeSH |
Aldehyde Dehydrogenase, Mitochondrial / genetics
Aldehyde Dehydrogenase, Mitochondrial / metabolism
Animals
Humans
Mice
Mice, Inbred C57BL
Muscle, Skeletal* / metabolism
Muscular Atrophy* / genetics
Muscular Atrophy* / metabolism
Reactive Oxygen Species / metabolism
|
| IF |
3.026
|
| Resource |
| Mice |
RBRC05808 |
