論文 - 詳細
| RRC ID | 70365 |
|---|---|
| 著者 | Ding X, Li Z, Peng K, Zou R, Wu C, Lin G, Li W, Xue L. |
| タイトル | Snail regulates Hippo signalling-mediated cell proliferation and tissue growth in Drosophila. |
| ジャーナル | Open Biol |
| Abstract |
Snail (Sna) plays a pivotal role in epithelia-mesenchymal transition and cancer metastasis, yet its functions in normal tissue development remain elusive. Here, using Drosophila as a model organism, we identified Sna as an essential regulator of Hippo signalling-mediated cell proliferation and tissue growth. First, Sna is necessary and sufficient for impaired Hippo signalling-induced cell proliferation and tissue overgrowth. Second, Sna is necessary and sufficient for the expression of Hippo pathway target genes. Third, genetic epistasis data indicate Sna acts downstream of Yki in the Hippo signalling. Finally, Sna is physiologically required for tissue growth in normal development. Mechanistically, Yki activates the transcription of sna, whose protein product binds to Scalloped (Sd) and promotes Sd-dependent cell proliferation. Thus, this study uncovered a previously unknown physiological function of Sna in normal tissue development and revealed the underlying mechanism by which Sna modulates Hippo signalling-mediated cell proliferation and tissue growth. |
| 巻・号 | 12(3) |
| ページ | 210357 |
| 公開日 | 2022-3-1 |
| DOI | 10.1098/rsob.210357 |
| PMID | 35259952 |
| PMC | PMC8905163 |
| MeSH | Animals Cell Proliferation Drosophila* / metabolism Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster / metabolism Intracellular Signaling Peptides and Proteins / genetics Intracellular Signaling Peptides and Proteins / metabolism Nuclear Proteins / genetics Nuclear Proteins / metabolism Protein Serine-Threonine Kinases / genetics Signal Transduction / physiology Trans-Activators / metabolism |
| IF | 4.931 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Peer-review(Publons) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 3956R-5 |