論文 - 詳細
| RRC ID | 70710 |
|---|---|
| 著者 | de Torres-Jurado A, Manzanero-Ortiz S, Carmena A. |
| タイトル | Glial-secreted Netrins regulate Robo1/Rac1-Cdc42 signaling threshold levels during Drosophila asymmetric neural stem/progenitor cell division. |
| ジャーナル | Curr Biol |
| Abstract |
Asymmetric stem cell division (ASCD) is a key mechanism in development, cancer, and stem cell biology. Drosophila neural stem cells, called neuroblasts (NBs), divide asymmetrically through intrinsic mechanisms. Here, we show that the extrinsic axon guidance cues Netrins, secreted by a glial niche surrounding larval brain neural stem cell lineages, regulate NB ASCD. Netrin-Frazzled/DCC signaling modulates, through Abelson kinase, Robo1 signaling threshold levels in Drosophila larval brain neural stem and progenitor cells of NBII lineages. Unbalanced Robo1 signaling levels induce ectopic NBs and progenitor cells due to failures in the ASCD process. Mechanistically, Robo1 signaling directly impinges on the intrinsic ASCD machinery, such as aPKC, Canoe/Afadin, and Numb, through the small GTPases Rac1 and Cdc42, which are required for the localization in mitotic NBs of Par-6, a Cdc42 physical partner and a core component of the Par (Par-6-aPKC-Par3/Bazooka) apical complex. |
| 巻・号 | 32(10) |
| ページ | 2174-2188.e3 |
| 公開日 | 2022-5-23 |
| DOI | 10.1016/j.cub.2022.04.001 |
| PII | S0960-9822(22)00566-8 |
| PMID | 35472309 |
| MeSH | Animals Asymmetric Cell Division Drosophila / metabolism Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster / physiology GTP-Binding Proteins Juvenile Hormones Larva / metabolism Nerve Tissue Proteins / genetics Netrins Neural Stem Cells* / metabolism Receptors, Immunologic |
| IF | 9.601 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 17 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#112830 |