論文 - 詳細
| RRC ID | 70771 |
|---|---|
| 著者 | Ding Y, Wang G, Zhan M, Sun X, Deng Y, Zhao Y, Liu B, Liu Q, Wu S, Zhou Z. |
| タイトル | Hippo signaling suppresses tumor cell metastasis via a Yki-Src42A positive feedback loop. |
| ジャーナル | Cell Death Dis |
| Abstract |
Metastasis is an important cause of death from malignant tumors. It is of great significance to explore the molecular mechanism of metastasis for the development of anti-cancer drugs. Here, we find that the Hippo pathway hampers tumor cell metastasis in vivo. Silence of hpo or its downstream wts promotes tumor cell migration in a Yki-dependent manner. Furthermore, we identify that inhibition of the Hippo pathway promotes tumor cell migration through transcriptional activating src42A, a Drosophila homolog of the SRC oncogene. Yki activates src42A transcription through direct binding its intron region. Intriguingly, Src42A further increases Yki transcriptional activity to form a positive feedback loop. Finally, we show that SRC is also a target of YAP and important for YAP to promote the migration of human hepatocellular carcinoma cells. Together, our findings uncover a conserved Yki/YAP-Src42A/SRC positive feedback loop promoting tumor cell migration and provide SRC as a potential therapeutic target for YAP-driven metastatic tumors. |
| 巻・号 | 12(12) |
| ページ | 1126 |
| 公開日 | 2021-12-3 |
| DOI | 10.1038/s41419-021-04423-y |
| PII | 10.1038/s41419-021-04423-y |
| PMID | 34862372 |
| PMC | PMC8642408 |
| MeSH | Animals Drosophila / metabolism Drosophila Proteins* / metabolism Drosophila melanogaster / metabolism Feedback Hippo Signaling Pathway Intracellular Signaling Peptides and Proteins / metabolism Neoplasms* / genetics Nuclear Proteins / metabolism Protein Serine-Threonine Kinases / genetics Proto-Oncogene Proteins pp60(c-src) / genetics Proto-Oncogene Proteins pp60(c-src) / metabolism Signal Transduction Trans-Activators / metabolism |
| IF | 6.304 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#102735 DGRC#109998 DGRC#108774 |