論文 - 詳細
| RRC ID | 71290 |
|---|---|
| 著者 | Igarashi M, Sawa R, Umekita M, Hatano M, Arisaka R, Hayashi C, Ishizaki Y, Suzuki M, Kato C. |
| タイトル | Sealutomicins, new enediyne antibiotics from the deep-sea actinomycete Nonomuraea sp. MM565M-173N2. |
| ジャーナル | J Antibiot (Tokyo) |
| Abstract |
A Nonomuraea sp. strain MM565M-173N2 was isolated from deep-sea sediment off the Sanriku coast, and new antibiotics were evaluated against carbapenem-resistant Enterobacteriaceae (CRE), which is a problematic group of bacteria because of their antimicrobial resistance. From 220 l of fermented broth from strain MM565M-173N2, we isolated four new antibiotics by gel filtration and HPLC, designated as sealutomicins A (1.8 mg), B (1.5 mg), C (0.8 mg), and D (0.8 mg). Their structures were determined from MS, NMR, and CD spectra. Sealutomicin A was found to be a new enediyne antibiotic, while sealutomicins B-D were aromatized products from sealutomicin A. Sealutomicin A showed strong antibacterial activity (MIC 0.05-0.2 μg ml-1) against CRE. |
| 巻・号 | 74(5) |
| ページ | 291-299 |
| 公開日 | 2021-5-1 |
| DOI | 10.1038/s41429-020-00402-1 |
| PII | 10.1038/s41429-020-00402-1 |
| PMID | 33531630 |
| MeSH | Actinobacteria / metabolism* Anti-Bacterial Agents / chemistry* Anti-Bacterial Agents / metabolism* Fermentation Geologic Sediments / microbiology Molecular Structure |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM5803 JCM5804 |