論文 - 詳細
| RRC ID | 7150 |
|---|---|
| 著者 | Hirose Y, Murosaki S, Fujiki T, Yamamoto Y, Yoshikai Y, Yamashita M. |
| タイトル | Lipoteichoic acids on Lactobacillus plantarum cell surfaces correlate with induction of interleukin-12p40 production. |
| ジャーナル | Microbiol Immunol |
| Abstract |
Heat-killed cells of Lactobacillus plantarum L-137 are potent inducers of IL-12 in vitro as well as in vivo and have been shown to have antiallergic, antitumor, and antiviral effects through this induction, which leads to a Th1 type immune response. To determine why L-137 cells induce much greater IL-12 production than the type strain Lactobacillus plantarum JCM1149, we examined the differences in their CW components. The L-137 CW was found to have a higher alanine content and IL-12p40 induction was significantly greater in comparison with JCM1149 CW, whereas peptidoglycans isolated from both strains did not cause IL-12p40 induction. Because in purified CW preparations from gram-positive bacteria, the presence of LTA, the major proinflammatory structure on these bacteria, has been known to have high alanine content, we investigated the responsiveness of both strains to anti-LTA antibody by flow cytometry. L-137 cells reacted more with anti-LTA antibody than did JCM1149 cells. Furthermore, derivative strains of L-137, cured of a specific plasmid pLTK11 of the 15 endogenous plasmids in wild-type L-137, had poor responsiveness to anti-LTA antibody and showed lower IL-12p40 inducing activity than the wild-type L-137 with pLTK11. Our results suggest that LTA expression on the cell surface causes IL-12p40 induction, and that the above internal plasmid of L-137 influences LTA synthesis and expression on the cell surface. |
| 巻・号 | 54(3) |
| ページ | 143-51 |
| 公開日 | 2010-3-1 |
| DOI | 10.1111/j.1348-0421.2009.00189.x |
| PII | MIM189 |
| PMID | 20236424 |
| MeSH | Animals Cell Wall / chemistry Cell Wall / immunology* Female Interleukin-12 Subunit p40 / genetics Interleukin-12 Subunit p40 / immunology* Lactobacillus plantarum / chemistry Lactobacillus plantarum / genetics Lactobacillus plantarum / immunology* Lipopolysaccharides / genetics Lipopolysaccharides / immunology* Mice Mice, Inbred BALB C Models, Animal Teichoic Acids / genetics Teichoic Acids / immunology* |
| IF | 1.566 |
| 引用数 | 18 |
| WOS 分野 | MICROBIOLOGY IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 11 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 1149 |