| RRC ID |
71649
|
| 著者 |
Hirota A, Taki S, Kawaii S, Yano M, Abe N.
|
| タイトル |
1,1-Diphenyl-2-picrylhydrazyl radical-scavenging compounds from soybean miso and antiproliferative activity of isoflavones from soybean miso toward the cancer cell lines.
|
| ジャーナル |
Biosci Biotechnol Biochem
|
| Abstract |
Guided by their DPPH radical-scavenging activity, nine compounds were isolated from soybean miso. Of these, 8-hydroxydaidzein, 8-hydroxygenistein and syringic acid had as high DPPH radical-scavenging activity as that of alpha-tocopherol. The antiproliferative activity of four of the isolated isoflavones toward three cancer cell lines was examined. 8-Hydroxygenistein showed the highest activity (IC50=5.2 microM) toward human promyelocytic leukemia cells (HL-60).
|
| 巻・号 |
64(5)
|
| ページ |
1038-40
|
| 公開日 |
2000-5-1
|
| DOI |
10.1271/bbb.64.1038
|
| PMID |
10879475
|
| MeSH |
Animals
Antineoplastic Agents, Phytogenic / pharmacology*
Bepridil / analogs & derivatives*
Biphenyl Compounds
Cell Division / drug effects*
Coumaric Acids / metabolism
Coumaric Acids / pharmacology
Drug Screening Assays, Antitumor
Fermentation
Free Radical Scavengers / isolation & purification*
Free Radical Scavengers / metabolism
Free Radical Scavengers / pharmacology*
Free Radicals
Genistein / metabolism
Genistein / pharmacology
Humans
Isoflavones / chemistry
Isoflavones / pharmacology*
Mice
Picrates*
Soybeans / chemistry*
Soybeans / metabolism
Tumor Cells, Cultured
|
| IF |
1.516
|
| リソース情報 |
| ヒト・動物細胞 |
HL60(RCB0041)
A549(RCB0098)
B16 melanoma 4A5(RCB0557) |
