RRC ID 72137
Author Zhang G, Zhang M, Yu J, Kang L, Guan H.
Title Ginsenoside Rg1 Prevents H2O2-induced Lens Opacity.
Journal Curr Eye Res
Abstract RESULTS:Exposure of 0.2 mM H2O2 in lenses resulted in obvious cloudiness and typical pathological changes of cataract such as rupture of the lens capsule, degenerative lens epithelial cells (LECs), etc. Rg1 effectively prevented lens opacity caused by H2O2. After Rg1 treatment, lens WSP content, the level of SOD, total GSH, and reduced GSH were increased, while the level of MDA and oxidized GSH were decreased. In addition, MDA concentration of lens by Rg1 treatment only was found to be lower than the controls. Rg1 attenuated H2O2-induced cell injury at the concentration of 0.4 mM that it elevated cell activity, and peaked at 0.6 mM.
CONCLUSIONS:This study demonstrated that Rg1 might have the capability to protect lens against oxidative stress-induced cataract, at least by local administration.Abbreviations: LECs: lens epithelial cells; Rg1: Ginsenoside Rg1; SD: Sprague-Dawley; ROS: reactive oxygen species; SOD: Superoxide Dismutase; GSH: glutathione; MDA: Malonediadehyde; H2O2: Hydrogen peroxide.
Volume 46(8)
Pages 1159-1165
Published 2021-8-1
DOI 10.1080/02713683.2020.1869266
PMID 33405968
MeSH Animals Cataract / chemically induced Cataract / metabolism Cataract / prevention & control* Cell Survival Cells, Cultured Central Nervous System Agents / therapeutic use* Ginsenosides / therapeutic use* Glutathione / metabolism Hydrogen Peroxide / toxicity* Malondialdehyde / metabolism Organ Culture Techniques Oxidants / toxicity* Oxidative Stress / drug effects Rats Rats, Sprague-Dawley Reactive Oxygen Species / metabolism Superoxide Dismutase / metabolism
IF 1.754
Human and Animal Cells SRA 01/04(RCB1591)