論文 - 詳細
| RRC ID | 72619 |
|---|---|
| 著者 | Nakagawa S, Matsuoka Y, Ichihara H, Yoshida H, Yoshida K, Ueoka R. |
| タイトル | Therapeutic effects of autologous lymphocytes activated with trastuzumab for xenograft mouse models of human breast cancer. |
| ジャーナル | Biol Pharm Bull |
| Abstract |
Trastuzumab (TTZ) is molecular targeted drug used for metastatic breast cancer patients overexpressing human epidermal growth factor receptor 2 (HER2). Therapeutic effects of lymphocytes activated with TTZ (TTZ-LAK) using xenograft mouse models of human breast cancer (MDA-MB-453) cells were examined in vivo. Remarkable reduction of tumor volume in a xenograft mouse models intravenously treated with TTZ-LAK cells after the subcutaneously inoculated of MDA-MB-453 cells was verified in vivo. The migration of TTZ-LAK cells in tumor of mouse models subcutaneously inoculated MDA-MB-453 cells was observed on the basis of histological analysis using immunostaining with CD-3. Induction of apoptosis in tumor of xenograft mice treated with TTZ-LAK cells was observed in micrographs using terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) method. It was noteworthy that the therapeutic effects of TTZ-LAK cells along with apoptosis were obtained for xenograft mouse models of human breast tumor in vivo. |
| 巻・号 | 36(5) |
| ページ | 861-5 |
| 公開日 | 2013-1-1 |
| DOI | 10.1248/bpb.b12-01084 |
| PII | DN/JST.JSTAGE/bpb/b12-01084 |
| PMID | 23649343 |
| MeSH | Animals Antibodies, Monoclonal, Humanized / administration & dosage* Antineoplastic Agents / administration & dosage* Apoptosis / drug effects Breast Neoplasms / pathology Breast Neoplasms / therapy* Cell Line, Tumor Female Humans Immunotherapy, Adoptive* Killer Cells, Lymphokine-Activated* Lymphocyte Activation Mice Mice, Inbred BALB C Trastuzumab Tumor Burden / drug effects Xenograft Model Antitumor Assays |
| IF | 1.863 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | MDA-MB-453(RCB1192) |