RRC ID 72643
著者 Hanaki Y, Miyoshi S, Sugiyama Y, Yanagita RC, Sato M.
タイトル 12-O-Tetradecanoylphorbol 13-acetate promotes proliferation and epithelial-mesenchymal transition in HHUA cells cultured on collagen type I gel: A feasible model to find new therapies for endometrial diseases.
ジャーナル Biosci Biotechnol Biochem
Abstract HHUA endometrial adenocarcinoma cells aggregated into spheroids when cultured on collagen type I gels. 12-O-Tetradecanoylphorbol 13-acetate, a PKC activator, disassembled the spheroids through epithelial-mesenchymal transition and increased their proliferation rate, while inducing cell death under monolayer culture conditions. These unusual behaviors of endometrial epithelial cells with collagen fibers could be a target for the treatment of some endometrial diseases.
巻・号 86(10)
ページ 1417-1422
公開日 2022-9-23
DOI 10.1093/bbb/zbac136
PII 6668795
PMID 35973688
MeSH Acetates / metabolism Cell Proliferation Cells, Cultured Collagen Type I / metabolism Endometrium / metabolism Endometrium / pathology Epithelial-Mesenchymal Transition* Female Gels / metabolism Humans Tetradecanoylphorbol Acetate / pharmacology Uterine Diseases*
IF 1.516
リソース情報
ヒト・動物細胞 HHUA(RCB0658)