論文 - 詳細
RRC ID | 72643 |
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著者 | Hanaki Y, Miyoshi S, Sugiyama Y, Yanagita RC, Sato M. |
タイトル | 12-O-Tetradecanoylphorbol 13-acetate promotes proliferation and epithelial-mesenchymal transition in HHUA cells cultured on collagen type I gel: A feasible model to find new therapies for endometrial diseases. |
ジャーナル | Biosci Biotechnol Biochem |
Abstract |
HHUA endometrial adenocarcinoma cells aggregated into spheroids when cultured on collagen type I gels. 12-O-Tetradecanoylphorbol 13-acetate, a PKC activator, disassembled the spheroids through epithelial-mesenchymal transition and increased their proliferation rate, while inducing cell death under monolayer culture conditions. These unusual behaviors of endometrial epithelial cells with collagen fibers could be a target for the treatment of some endometrial diseases. |
巻・号 | 86(10) |
ページ | 1417-1422 |
公開日 | 2022-9-23 |
DOI | 10.1093/bbb/zbac136 |
PII | 6668795 |
PMID | 35973688 |
MeSH | Acetates / metabolism Cell Proliferation Cells, Cultured Collagen Type I / metabolism Endometrium / metabolism Endometrium / pathology Epithelial-Mesenchymal Transition* Female Gels / metabolism Humans Tetradecanoylphorbol Acetate / pharmacology Uterine Diseases* |
IF | 1.516 |
リソース情報 | |
ヒト・動物細胞 | HHUA(RCB0658) |