論文 - 詳細
| RRC ID | 72680 |
|---|---|
| 著者 | Takamatsu G, Manome Y, Lee JS, Toyama K, Hayakawa T, Hara-Miyauchi C, Hasegawa-Ogawa M, Katagiri C, Kondo T, James Okano H, Matsushita M. |
| タイトル | Generation of four iPSC lines from a family harboring a 1p36-35 haplotype linked with bipolar disorder and recurrent depressive disorder: Three-generation patients and a healthy sibling. |
| ジャーナル | Stem Cell Res |
| Abstract |
Induced pluripotent stem cells (iPSCs) obtained from genetically characterized patients benefit the biological study of bipolar disorder (BD). Here, we present iPSC lines from three-generation patients with BD and recurrent depressive disorder (RDD) and a healthy control sibling in a family. All patients shared the specified haplotype in the 1p36-35, previously reported as the susceptibility locus of mood disorders. iPSCs were generated with the reprogramming factors OTC3/4, l-MYC, LIN28, SOX2, KLF4, and p53 shRNA through non-integrated episomal vectors. All iPSC lines strongly expressed pluripotency markers and proved the ability to differentiate into three germ lineages in vitro. |
| 巻・号 | 64 |
| ページ | 102915 |
| 公開日 | 2022-10-1 |
| DOI | 10.1016/j.scr.2022.102915 |
| PII | S1873-5061(22)00264-1 |
| PMID | 36166871 |
| MeSH | Bipolar Disorder* / genetics Depressive Disorder* Haplotypes / genetics Humans Induced Pluripotent Stem Cells* RNA, Small Interfering Siblings Tumor Suppressor Protein p53 |
| IF | 4.495 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | 1383D6(HPS1006) |