論文 - 詳細
| RRC ID | 72809 |
|---|---|
| 著者 | Oura S, Hino T, Satoh T, Noda T, Koyano T, Isotani A, Matsuyama M, Akira S, Ishiguro KI, Ikawa M. |
| タイトル | Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice. |
| ジャーナル | PLoS Genet |
| Abstract |
Meiosis is a hallmark event in germ cell development that accompanies sequential events executed by numerous molecules. Therefore, characterization of these factors is one of the best strategies to clarify the mechanism of meiosis. Here, we report tripartite motif-containing 41 (TRIM41), a ubiquitin ligase E3, as an essential factor for proper meiotic progression and fertility in male mice. Trim41 knockout (KO) spermatocytes exhibited synaptonemal complex protein 3 (SYCP3) overloading, especially on the X chromosome. Furthermore, mutant mice lacking the RING domain of TRIM41, required for the ubiquitin ligase E3 activity, phenocopied Trim41 KO mice. We then examined the behavior of mutant TRIM41 (ΔRING-TRIM41) and found that ΔRING-TRIM41 accumulated on the chromosome axes with overloaded SYCP3. This result suggested that TRIM41 exerts its function on the chromosome axes. Our study revealed that Trim41 is essential for preventing SYCP3 overloading, suggesting a TRIM41-mediated mechanism for regulating chromosome axis protein dynamics during male meiotic progression. |
| 巻・号 | 18(6) |
| ページ | e1010241 |
| 公開日 | 2022-6-1 |
| DOI | 10.1371/journal.pgen.1010241 |
| PII | PGENETICS-D-22-00112 |
| PMID | 35648791 |
| PMC | PMC9191731 |
| MeSH | Animals Cell Cycle Proteins / genetics Cell Cycle Proteins / metabolism Male Meiosis / genetics Mice Mice, Knockout Nuclear Proteins* / genetics Nuclear Proteins* / metabolism Spermatocytes / metabolism Synaptonemal Complex* / genetics Synaptonemal Complex* / metabolism Ubiquitin-Protein Ligases / genetics Ubiquitin-Protein Ligases / metabolism* |
| IF | 5.175 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | pClgn1.1-Trim41-PA-1D4 (RDB19656) |