論文 - 詳細
| RRC ID | 72822 |
|---|---|
| 著者 | Kwon OS, Kim D, Kim H, Lee YJ, Lee HS, Sim CJ, Oh DC, Lee SK, Oh KB, Shin J. |
| タイトル | Bromopyrrole Alkaloids from the Sponge Agelas kosrae. |
| ジャーナル | Mar Drugs |
| Abstract |
Two new sceptrin derivatives (1,2) and eight structurally-related known bromopyrrole-bearing alkaloids were isolated from the tropical sponge Agelas kosrae. By a combination of spectroscopic methods, the new compounds, designated dioxysceptrin (1) and ageleste C (2), were determined to be structural analogs of each other that differ at the imidazole moiety. Dioxysceptrin was also found to exist as a mixture of α-amido epimers. The sceptrin alkaloids exhibited weak cytotoxicity against cancer cells. Compounds 1 and 2 also moderately exhibited anti-angiogenic and isocitrate lyase-inhibitory activities, respectively. |
| 巻・号 | 16(12) |
| 公開日 | 2018-12-17 |
| DOI | 10.3390/md16120513 |
| PII | md16120513 |
| PMID | 30563015 |
| PMC | PMC6316234 |
| MeSH | Agelas / chemistry* Alkaloids / chemistry Alkaloids / isolation & purification Alkaloids / pharmacology* Angiogenesis Inhibitors / chemistry Angiogenesis Inhibitors / isolation & purification Angiogenesis Inhibitors / pharmacology Animals Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification Antineoplastic Agents / pharmacology Biological Products / isolation & purification Biological Products / pharmacology* Cell Line, Tumor Drug Screening Assays, Antitumor Enzyme Assays Human Umbilical Vein Endothelial Cells Humans Isocitrate Lyase / antagonists & inhibitors Pyrroles / chemistry Pyrroles / isolation & purification Pyrroles / pharmacology* Stereoisomerism |
| IF | 4.073 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Peer-review(Publons) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 病原真核微生物 | Trichophyton mentagrophytes IFM 40997 |