RRC ID 72927
Author Tanaka T, Mizuno K, Umesaki N, Ogita S.
Title Suppressed apoptotic susceptibility in human endometrial epithelial cells pretreated with hepatocyte growth factor.
Journal Clin Exp Obstet Gynecol
Abstract Hepatocyte growth factor (HGF) and its receptor are strongly expressed perimenstrually in human endometrial epithelium, but their functions remain unknown. In this study the effects of HGF on Fas-mediated apoptosis in the human endometrial epithelial cell line HHUA were investigated. It was found that HGF inhibited Fas-mediated growth suppression and DNA fragmentation in the cells without any increase in Fas antigen expression on the cells. This results suggests that HGF inhibits Fas-mediated apoptotic signals in the endometrium, and possibly plays a role in reshaping the endometrium during menstruation.
Volume 25(4)
Pages 125-8
Published 1998-1-1
PMID 9987568
MeSH Adenocarcinoma / pathology* Apoptosis* Cell Division / drug effects DNA Fragmentation Dose-Response Relationship, Drug Endometrial Neoplasms / pathology* Endometrium / cytology* Endometrium / drug effects Epithelium / pathology Female Flow Cytometry Hepatocyte Growth Factor / metabolism* Hepatocyte Growth Factor / pharmacology Humans Menstruation / metabolism Proto-Oncogene Proteins c-met / metabolism* Tumor Cells, Cultured / pathology fas Receptor / metabolism
Human and Animal Cells HHUA(RCB0658)