| RRC ID |
73493
|
| 著者 |
Maehara K, Murata T, Aoyama N, Matsuno K, Sawamura K.
|
| タイトル |
Genetic dissection of Nucleoporin 160 (Nup160), a gene involved in multiple phenotypes of reproductive isolation in Drosophila.
|
| ジャーナル |
Genes Genet Syst
|
| Abstract |
Previous reports have suggested that the Nucleoporin 160 (Nup160) gene of Drosophila simulans (Nup160(sim)) causes the hybrid inviability, female sterility, and morphological anomalies that are observed in crosses with D. melanogaster. Here we have confirmed this observation by transposon excision from the P{EP}Nup160(EP372) insertion mutation of D. melanogaster. Null mutations of the Nup160 gene resulted in the three phenotypes caused by Nup160(sim), but revertants of the gene did not. Interestingly, several mutations produced by excision partially complemented hybrid inviability, female sterility, or morphological anomalies. In the future, these mutations will be useful to further our understanding of the developmental mechanisms of reproductive isolation. Based on our analyses with the Nup160(sim) introgression line, the lethal phase of hybrid inviability was determined to be during the early pupal stage. Our analysis also suggested that homozygous Nup160(sim) in D. melanogaster leads to slow development. Thus, Nup160(sim) is involved in multiple aspects of reproductive isolation between these two species.
|
| 巻・号 |
87(2)
|
| ページ |
99-106
|
| 公開日 |
2012-1-1
|
| DOI |
10.1266/ggs.87.99
|
| PII |
DN/JST.JSTAGE/ggs/87.99
|
| PMID |
22820383
|
| MeSH |
Animals
Crosses, Genetic
Drosophila / genetics*
Female
Genes, Insect*
Genes, Lethal
Homozygote
Hybridization, Genetic
Infertility, Female / genetics
Male
Mutation
Nuclear Pore Complex Proteins / genetics*
Nuclear Pore Complex Proteins / metabolism
Phenotype
Reproductive Isolation*
|
| IF |
0.917
|
| リソース情報 |
| ショウジョウバエ |
DGRC#118827 |
