| RRC ID |
73561
|
| 著者 |
Saito M, Chiba A, Sato T, Moriya T, Sukegawa J, Nakahata N.
|
| タイトル |
Tctex-1 augments G protein-coupled receptor-mediated Gs signaling by activating adenylyl cyclase.
|
| ジャーナル |
J Pharmacol Sci
|
| Abstract |
Proteins interacting with G protein-coupled receptors (GPCRs) can modulate signal transduction of these receptors. However, the regulatory mechanisms of the interacting proteins are diverse and largely unknown. We have previously shown that Tctex-1 (or DYNLT1) can interact with the parathyroid hormone receptor (PTHR). In the present study, we investigated the role of Tctex-1 in the PTHR signaling and found that Tctex-1 augmented the PTHR-mediated Gs/adenylyl cyclase (AC) pathway by activating AC regardless of the binding to PTHR. Furthermore, Tctex-1 directly bound to AC type 6. These data demonstrate a novel mechanism underlying GPCR/Gs signaling regulated by Tctex-1.
|
| 巻・号 |
145(1)
|
| ページ |
150-154
|
| 公開日 |
2021-1-1
|
| DOI |
10.1016/j.jphs.2020.11.011
|
| PII |
S1347-8613(20)30117-1
|
| PMID |
33357773
|
| MeSH |
3T3 Cells
Adenylyl Cyclases / metabolism*
Animals
Dyneins / metabolism*
Dyneins / physiology*
HEK293 Cells
Humans
Mice
Protein Binding
Receptor, Parathyroid Hormone, Type 1 / metabolism
Receptor, Parathyroid Hormone, Type 1 / physiology
Receptors, G-Protein-Coupled / metabolism*
Signal Transduction / drug effects*
Signal Transduction / genetics*
|
| IF |
2.835
|
| リソース情報 |
| ヒト・動物細胞 |
MC3T3-E1(RCB1126) |
