Reference - Detail
| RRC ID | 73745 |
|---|---|
| Author | Chacko LA, Mikus F, Ariotti N, Dey G, Ananthanarayanan V. |
| Title | Microtubule-mitochondrial attachment facilitates cell division symmetry and mitochondrial partitioning in fission yeast. |
| Journal | J Cell Sci |
| Abstract |
Association with microtubules inhibits the fission of mitochondria in Schizosaccharomyces pombe. Here, we show that this attachment of mitochondria to microtubules is an important cell-intrinsic factor in determining cell division symmetry. By comparing mutant cells that exhibited enhanced attachment and no attachment of mitochondria to microtubules (Dnm1Δ and Mmb1Δ, respectively), we show that microtubules in these mutants displayed aberrant dynamics compared to wild-type cells, which resulted in errors in nuclear positioning. This translated to cell division asymmetry in a significant proportion of both Dnm1Δ and Mmb1Δ cells. Asymmetric division in Dnm1Δ and Mmb1Δ cells resulted in unequal distribution of mitochondria, with the daughter cell that received more mitochondria growing faster than the other daughter cell. Taken together, we show the existence of homeostatic feedback controls between mitochondria and microtubules in fission yeast, which directly influence mitochondrial partitioning and, thereby, cell growth. This article has an associated First Person interview with the first author of the paper. |
| Volume | 136(1) |
| Published | 2023-1-1 |
| DOI | 10.1242/jcs.260705 |
| PII | 286576 |
| PMID | 36633091 |
| MeSH | Cell Division / genetics Humans Microtubules / genetics Microtubules / metabolism Mitochondria / genetics Schizosaccharomyces* / genetics Schizosaccharomyces pombe Proteins* / genetics Schizosaccharomyces pombe Proteins* / metabolism |
| IF | 4.573 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 17 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Yeast | FY7143 FY31851 |