論文 - 詳細
RRC ID | 73804 |
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著者 | Moriyama T, Kataoka H, Hamasuna R, Yokogami K, Uehara H, Kawano H, Goya T, Tsubouchi H, Koono M, Wakisaka S. |
タイトル | Up-regulation of vascular endothelial growth factor induced by hepatocyte growth factor/scatter factor stimulation in human glioma cells. |
ジャーナル | Biochem Biophys Res Commun |
Abstract |
Recent findings suggest that hepatocyte growth factor/scatter factor (HGF/SF) contributes to the malignant progression of human gliomas. We investigated the effect of HGF/SF on vascular endothelial growth factor (VEGF) expression of c-Met/HGF receptor-positive human glioma cell lines. Treatment of the glioma cells with various concentrations of HGF/SF resulted in an enhanced secretion of VEGF proteins accompanying increased transcription of VEGF mRNA in a dose-dependent fashion. Since malignant gliomas frequently co-express HGF/SF and its receptor, these results suggest that HGF/SF could act as an indirect angiogenic factor through autocrine induction of VEGF expression and secretion in malignant gliomas. |
巻・号 | 249(1) |
ページ | 73-7 |
公開日 | 1998-8-10 |
DOI | 10.1006/bbrc.1998.9078 |
PII | S0006-291X(98)99078-7 |
PMID | 9705834 |
MeSH | Endothelial Growth Factors / biosynthesis* Glioma / metabolism* Hepatocyte Growth Factor / pharmacology* Humans Lymphokines / biosynthesis* Tumor Cells, Cultured Up-Regulation / drug effects Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors |
IF | 2.985 |
リソース情報 | |
ヒト・動物細胞 | KG-1-C(RCB0270) |