| RRC ID |
74850
|
| Author |
Azuma K, Urano T, Ouchi Y, Inoue S.
|
| Title |
Vitamin K2 suppresses proliferation and motility of hepatocellular carcinoma cells by activating steroid and xenobiotic receptor.
|
| Journal |
Endocr J
|
| Abstract |
Vitamin K2, known as a cofactor for gamma-carboxylase, also serves as a ligand of a nuclear receptor, Steroid and Xenobiotic Receptor (SXR). Several clinical trials revealed that vitamin K2 reduced de novo formation and recurrence of hepatocellular carcinoma (HCC). To examine the role of SXR in HCC as a receptor activated by vitamin K2, the cells stably overexpressing SXR were established using a HCC cell line, HuH7. Overexpression of SXR resulted in reduced proliferation and motility of the cells. Further suppression of proliferation and motility was observed when SXR overexpressing clones were treated with vitamin K2. These results suggest that the activation of SXR could contribute to tumor suppressive effects of vitamin K2 on HCC cells.
|
| Volume |
56(7)
|
| Pages |
843-9
|
| Published |
2009-1-1
|
| DOI |
10.1507/endocrj.k09e-108
|
| PII |
JST.JSTAGE/endocrj/K09E-108
|
| PMID |
19550077
|
| MeSH |
Carcinoma, Hepatocellular / drug therapy*
Carcinoma, Hepatocellular / pathology
Carcinoma, Hepatocellular / physiopathology
Cell Line, Tumor
Cell Movement / drug effects*
Cell Proliferation / drug effects*
Hep G2 Cells
Humans
Liver Neoplasms / drug therapy*
Liver Neoplasms / pathology
Pregnane X Receptor
Receptors, Steroid / drug effects
Receptors, Steroid / physiology*
Rifampin / pharmacology
Vitamin K 2 / analogs & derivatives
Vitamin K 2 / pharmacology
Vitamin K 2 / therapeutic use*
|
| IF |
1.952
|
| Resource |
| Human and Animal Cells |
HuH-7(RCB1366) |
