RRC ID 74850
Author Azuma K, Urano T, Ouchi Y, Inoue S.
Title Vitamin K2 suppresses proliferation and motility of hepatocellular carcinoma cells by activating steroid and xenobiotic receptor.
Journal Endocr J
Abstract Vitamin K2, known as a cofactor for gamma-carboxylase, also serves as a ligand of a nuclear receptor, Steroid and Xenobiotic Receptor (SXR). Several clinical trials revealed that vitamin K2 reduced de novo formation and recurrence of hepatocellular carcinoma (HCC). To examine the role of SXR in HCC as a receptor activated by vitamin K2, the cells stably overexpressing SXR were established using a HCC cell line, HuH7. Overexpression of SXR resulted in reduced proliferation and motility of the cells. Further suppression of proliferation and motility was observed when SXR overexpressing clones were treated with vitamin K2. These results suggest that the activation of SXR could contribute to tumor suppressive effects of vitamin K2 on HCC cells.
Volume 56(7)
Pages 843-9
Published 2009-1-1
DOI 10.1507/endocrj.k09e-108
PII JST.JSTAGE/endocrj/K09E-108
PMID 19550077
MeSH Carcinoma, Hepatocellular / drug therapy* Carcinoma, Hepatocellular / pathology Carcinoma, Hepatocellular / physiopathology Cell Line, Tumor Cell Movement / drug effects* Cell Proliferation / drug effects* Hep G2 Cells Humans Liver Neoplasms / drug therapy* Liver Neoplasms / pathology Pregnane X Receptor Receptors, Steroid / drug effects Receptors, Steroid / physiology* Rifampin / pharmacology Vitamin K 2 / analogs & derivatives Vitamin K 2 / pharmacology Vitamin K 2 / therapeutic use*
IF 1.952
Human and Animal Cells HuH-7(RCB1366)