RRC ID 75982
Author Jiang HS, Ghose P, Han HF, Wu YZ, Tsai YY, Lin HC, Tseng WC, Wu JC, Shaham S, Wu YC.
Title BLMP-1 promotes developmental cell death in C. elegans by timely repression of ced-9 transcription.
Journal Development
Abstract Programmed cell death (PCD) is a common cell fate in metazoan development. PCD effectors are extensively studied, but how they are temporally regulated is less understood. Here, we report a mechanism controlling tail-spike cell death onset during Caenorhabditis elegans development. We show that the zinc-finger transcription factor BLMP-1, which controls larval development timing, also regulates embryonic tail-spike cell death initiation. BLMP-1 functions upstream of CED-9 and in parallel to DRE-1, another CED-9 and tail-spike cell death regulator. BLMP-1 expression is detected in the tail-spike cell shortly after the cell is born, and blmp-1 mutations promote ced-9-dependent tail-spike cell survival. BLMP-1 binds ced-9 gene regulatory sequences, and inhibits ced-9 transcription just before cell-death onset. BLMP-1 and DRE-1 function together to regulate developmental timing, and their mammalian homologs regulate B-lymphocyte fate. Our results, therefore, identify roles for developmental timing genes in cell-death initiation, and suggest conservation of these functions.
Volume 148(20)
Published 2021-10-15
DOI 10.1242/dev.193995
PII 272221
PMID 34541605
PMC PMC8572009
MeSH Animals Apoptosis / genetics Caenorhabditis elegans / genetics* Caenorhabditis elegans Proteins / genetics* Cell Death / genetics* Cell Differentiation / genetics Gene Expression Regulation, Developmental / genetics Repressor Proteins / genetics* Transcription, Genetic / genetics*
Resource
C.elegans tm548