論文 - 詳細
| RRC ID | 75982 |
|---|---|
| 著者 | Jiang HS, Ghose P, Han HF, Wu YZ, Tsai YY, Lin HC, Tseng WC, Wu JC, Shaham S, Wu YC. |
| タイトル | BLMP-1 promotes developmental cell death in C. elegans by timely repression of ced-9 transcription. |
| ジャーナル | Development |
| Abstract |
Programmed cell death (PCD) is a common cell fate in metazoan development. PCD effectors are extensively studied, but how they are temporally regulated is less understood. Here, we report a mechanism controlling tail-spike cell death onset during Caenorhabditis elegans development. We show that the zinc-finger transcription factor BLMP-1, which controls larval development timing, also regulates embryonic tail-spike cell death initiation. BLMP-1 functions upstream of CED-9 and in parallel to DRE-1, another CED-9 and tail-spike cell death regulator. BLMP-1 expression is detected in the tail-spike cell shortly after the cell is born, and blmp-1 mutations promote ced-9-dependent tail-spike cell survival. BLMP-1 binds ced-9 gene regulatory sequences, and inhibits ced-9 transcription just before cell-death onset. BLMP-1 and DRE-1 function together to regulate developmental timing, and their mammalian homologs regulate B-lymphocyte fate. Our results, therefore, identify roles for developmental timing genes in cell-death initiation, and suggest conservation of these functions. |
| 巻・号 | 148(20) |
| 公開日 | 2021-10-15 |
| DOI | 10.1242/dev.193995 |
| PII | 272221 |
| PMID | 34541605 |
| PMC | PMC8572009 |
| MeSH | Animals Apoptosis / genetics Caenorhabditis elegans / genetics* Caenorhabditis elegans Proteins / genetics* Cell Death / genetics* Cell Differentiation / genetics Gene Expression Regulation, Developmental / genetics Repressor Proteins / genetics* Transcription, Genetic / genetics* |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm548 |