RRC ID 75988
Author Kim H, Ding YH, Zhang G, Yan YH, Conte D Jr, Dong MQ, Mello CC.
Title HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans.
Journal Elife
Abstract Eukaryotic cells use guided search to coordinately control dispersed genetic elements. Argonaute proteins and their small RNA cofactors engage nascent RNAs and chromatin-associated proteins to direct transcriptional silencing. The small ubiquitin-like modifier (SUMO) has been shown to promote the formation and maintenance of silent chromatin (called heterochromatin) in yeast, plants, and animals. Here, we show that Argonaute-directed transcriptional silencing in Caenorhabditis elegans requires SUMOylation of the type 1 histone deacetylase HDA-1. Our findings suggest how SUMOylation promotes the association of HDAC1 with chromatin remodeling factors and with a nuclear Argonaute to initiate de novo heterochromatin silencing.
Volume 10
Published 2021-5-18
DOI 10.7554/eLife.63299
PII 63299
PMID 34003109
PMC PMC8131101
MeSH Animals Argonaute Proteins / genetics* Argonaute Proteins / metabolism Caenorhabditis elegans / genetics* Chromatin Assembly and Disassembly Gene Silencing Heterochromatin / genetics Heterochromatin / metabolism Histone Deacetylase 1 / genetics* Histone Deacetylase 1 / metabolism* RNA Interference RNA, Small Interfering Sumoylation* Transcription, Genetic*
C.elegans tm872 tm1200 tm1276