論文 - 詳細
| RRC ID | 75988 |
|---|---|
| 著者 | Kim H, Ding YH, Zhang G, Yan YH, Conte D Jr, Dong MQ, Mello CC. |
| タイトル | HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans. |
| ジャーナル | Elife |
| Abstract |
Eukaryotic cells use guided search to coordinately control dispersed genetic elements. Argonaute proteins and their small RNA cofactors engage nascent RNAs and chromatin-associated proteins to direct transcriptional silencing. The small ubiquitin-like modifier (SUMO) has been shown to promote the formation and maintenance of silent chromatin (called heterochromatin) in yeast, plants, and animals. Here, we show that Argonaute-directed transcriptional silencing in Caenorhabditis elegans requires SUMOylation of the type 1 histone deacetylase HDA-1. Our findings suggest how SUMOylation promotes the association of HDAC1 with chromatin remodeling factors and with a nuclear Argonaute to initiate de novo heterochromatin silencing. |
| 巻・号 | 10 |
| 公開日 | 2021-5-18 |
| DOI | 10.7554/eLife.63299 |
| PII | 63299 |
| PMID | 34003109 |
| PMC | PMC8131101 |
| MeSH | Animals Argonaute Proteins / genetics* Argonaute Proteins / metabolism Caenorhabditis elegans / genetics* Chromatin Assembly and Disassembly Gene Silencing Heterochromatin / genetics Heterochromatin / metabolism Histone Deacetylase 1 / genetics* Histone Deacetylase 1 / metabolism* RNA Interference RNA, Small Interfering Sumoylation* Transcription, Genetic* |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm872 tm1200 tm1276 |