| RRC ID |
75988
|
| Author |
Kim H, Ding YH, Zhang G, Yan YH, Conte D Jr, Dong MQ, Mello CC.
|
| Title |
HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans.
|
| Journal |
Elife
|
| Abstract |
Eukaryotic cells use guided search to coordinately control dispersed genetic elements. Argonaute proteins and their small RNA cofactors engage nascent RNAs and chromatin-associated proteins to direct transcriptional silencing. The small ubiquitin-like modifier (SUMO) has been shown to promote the formation and maintenance of silent chromatin (called heterochromatin) in yeast, plants, and animals. Here, we show that Argonaute-directed transcriptional silencing in Caenorhabditis elegans requires SUMOylation of the type 1 histone deacetylase HDA-1. Our findings suggest how SUMOylation promotes the association of HDAC1 with chromatin remodeling factors and with a nuclear Argonaute to initiate de novo heterochromatin silencing.
|
| Volume |
10
|
| Published |
2021-5-18
|
| DOI |
10.7554/eLife.63299
|
| PII |
63299
|
| PMID |
34003109
|
| PMC |
PMC8131101
|
| MeSH |
Animals
Argonaute Proteins / genetics*
Argonaute Proteins / metabolism
Caenorhabditis elegans / genetics*
Chromatin Assembly and Disassembly
Gene Silencing
Heterochromatin / genetics
Heterochromatin / metabolism
Histone Deacetylase 1 / genetics*
Histone Deacetylase 1 / metabolism*
RNA Interference
RNA, Small Interfering
Sumoylation*
Transcription, Genetic*
|
| Resource |
| C.elegans |
tm872
tm1200
tm1276 |
