論文 - 詳細
| RRC ID | 76001 |
|---|---|
| 著者 | Lin-Moore AT, Oyeyemi MJ, Hammarlund M. |
| タイトル | rab-27 acts in an intestinal pathway to inhibit axon regeneration in C. elegans. |
| ジャーナル | PLoS Genet |
| Abstract |
Injured axons must regenerate to restore nervous system function, and regeneration is regulated in part by external factors from non-neuronal tissues. Many of these extrinsic factors act in the immediate cellular environment of the axon to promote or restrict regeneration, but the existence of long-distance signals regulating axon regeneration has not been clear. Here we show that the Rab GTPase rab-27 inhibits regeneration of GABAergic motor neurons in C. elegans through activity in the intestine. Re-expression of RAB-27, but not the closely related RAB-3, in the intestine of rab-27 mutant animals is sufficient to rescue normal regeneration. Several additional components of an intestinal neuropeptide secretion pathway also inhibit axon regeneration, including NPDC1/cab-1, SNAP25/aex-4, KPC3/aex-5, and the neuropeptide NLP-40, and re-expression of these genes in the intestine of mutant animals is sufficient to restore normal regeneration success. Additionally, NPDC1/cab-1 and SNAP25/aex-4 genetically interact with rab-27 in the context of axon regeneration inhibition. Together these data indicate that RAB-27-dependent neuropeptide secretion from the intestine inhibits axon regeneration, and point to distal tissues as potent extrinsic regulators of regeneration. |
| 巻・号 | 17(11) |
| ページ | e1009877 |
| 公開日 | 2021-11-1 |
| DOI | 10.1371/journal.pgen.1009877 |
| PII | PGENETICS-D-21-00078 |
| PMID | 34818334 |
| PMC | PMC8612575 |
| MeSH | Animals Axons / physiology* Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* GABAergic Neurons / physiology* Intestines / metabolism* Regeneration* Signal Transduction Synaptic Vesicles / metabolism rab GTP-Binding Proteins / genetics rab GTP-Binding Proteins / metabolism* rab27 GTP-Binding Proteins / genetics rab27 GTP-Binding Proteins / metabolism* |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 18 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm4085 tm2526 |