論文 - 詳細
| RRC ID | 76129 |
|---|---|
| 著者 | Bujarrabal-Dueso A, Sendtner G, Meyer DH, Chatzinikolaou G, Stratigi K, Garinis GA, Schumacher B. |
| タイトル | The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities. |
| ジャーナル | Nat Struct Mol Biol |
| Abstract |
The DNA-repair capacity in somatic cells is limited compared with that in germ cells. It has remained unknown whether not only lesion-type-specific, but overall repair capacities could be improved. Here we show that the DREAM repressor complex curbs the DNA-repair capacities in somatic tissues of Caenorhabditis elegans. Mutations in the DREAM complex induce germline-like expression patterns of multiple mechanisms of DNA repair in the soma. Consequently, DREAM mutants confer resistance to a wide range of DNA-damage types during development and aging. Similarly, inhibition of the DREAM complex in human cells boosts DNA-repair gene expression and resistance to distinct DNA-damage types. DREAM inhibition leads to decreased DNA damage and prevents photoreceptor loss in progeroid Ercc1-/- mice. We show that the DREAM complex transcriptionally represses essentially all DNA-repair systems and thus operates as a highly conserved master regulator of the somatic limitation of DNA-repair capacities. |
| 巻・号 | 30(4) |
| ページ | 475-488 |
| 公開日 | 2023-4-1 |
| DOI | 10.1038/s41594-023-00942-8 |
| PII | 10.1038/s41594-023-00942-8 |
| PMID | 36959262 |
| PMC | PMC10113156 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism DNA / metabolism DNA Damage DNA Repair Germ Cells / metabolism Humans Mice |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 571 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 9.5 |
| リソース情報 | |
| 線虫 | tm3886 tm1489 tm4539 tm1524 tm1145 |