論文 - 詳細
| RRC ID | 76207 |
|---|---|
| 著者 | Kawano T, Kashiwagi M, Kanuka M, Chen CK, Yasugaki S, Hatori S, Miyazaki S, Tanaka K, Fujita H, Nakajima T, Yanagisawa M, Nakagawa Y, Hayashi Y. |
| タイトル | ER proteostasis regulators cell-non-autonomously control sleep. |
| ジャーナル | Cell Rep |
| Abstract |
Sleep is regulated by peripheral tissues under fatigue. The molecular pathways in peripheral cells that trigger systemic sleep-related signals, however, are unclear. Here, a forward genetic screen in C. elegans identifies 3 genes that strongly affect sleep amount: sel-1, sel-11, and mars-1. sel-1 and sel-11 encode endoplasmic reticulum (ER)-associated degradation components, whereas mars-1 encodes methionyl-tRNA synthetase. We find that these machineries function in non-neuronal tissues and that the ER unfolded protein response components inositol-requiring enzyme 1 (IRE1)/XBP1 and protein kinase R-like ER kinase (PERK)/eukaryotic initiation factor-2α (eIF2α)/activating transcription factor-4 (ATF4) participate in non-neuronal sleep regulation, partly by reducing global translation. Neuronal epidermal growth factor receptor (EGFR) signaling is also required. Mouse studies suggest that this mechanism is conserved in mammals. Considering that prolonged wakefulness increases ER proteostasis stress in peripheral tissues, our results suggest that peripheral ER proteostasis factors control sleep homeostasis. Moreover, based on our results, peripheral tissues likely cope with ER stress not only by the well-established cell-autonomous mechanisms but also by promoting the individual's sleep. |
| 巻・号 | 42(3) |
| ページ | 112267 |
| 公開日 | 2023-3-28 |
| DOI | 10.1016/j.celrep.2023.112267 |
| PII | S2211-1247(23)00278-4 |
| PMID | 36924492 |
| MeSH | Activating Transcription Factor 4 / genetics Activating Transcription Factor 4 / metabolism Animals Caenorhabditis elegans* / genetics Caenorhabditis elegans* / metabolism Endoplasmic Reticulum Stress / physiology Mammals / metabolism Mice Proteostasis* Signal Transduction Unfolded Protein Response eIF-2 Kinase / genetics eIF-2 Kinase / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 91 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.2 |
| リソース情報 | |
| 線虫 | tm4397 tm1340 tm1944 |
| ヒト・動物細胞 | 293T(RCB2202) |