RRC ID 77017
Author Fujisawa K, Terai S, Matsumoto T, Takami T, Yamamoto N, Nishina H, Furutani-Seiki M, Sakaida I.
Title Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging.
Journal PLoS One
Abstract Maid is a helix-loop-helix protein that is involved in cell proliferation. In order to further elucidate its physiological functions, we studied Maid activity in two small fish model systems. We found that Maid expression was greatest in zebrafish liver and that it increased following partial hepatectomy. Maid levels were also high in hepatic preneoplastic foci induced by treatment of zebrafish with diethylnitrosamine (DEN), but low in hepatocellular carcinomas (HCC), mixed tumors, and cholangiocarcinomas developing in these animals. In DEN-treated transgenic medaka overexpressing Maid, hepatic BrdU uptake and proliferation were reduced. After successive breedings, Maid transgenic medaka exhibited decreased movement and a higher incidence of abnormal spine curvature, possibly due to the senescence of spinal cord cells. Taken together, our results suggest that Maid levels can influence the progression of liver cancer. In conclusion, we found that Maid is important regulator of hepatocarconogenesis and aging.
Volume 10(6)
Pages e0129950
Published 2015-1-1
DOI 10.1371/journal.pone.0129950
PII PONE-D-14-44140
PMID 26107180
PMC PMC4479567
MeSH Aging / genetics* Amino Acid Sequence Animals Animals, Genetically Modified Carcinogenesis / genetics* Carcinoma, Hepatocellular / metabolism Cell Line Cell Transformation, Neoplastic* Diethylnitrosamine / chemistry Disease Models, Animal Disease Progression Gene Expression Profiling Gene Expression Regulation, Neoplastic* Humans Liver Neoplasms / metabolism Mice Molecular Sequence Data Oligonucleotide Array Sequence Analysis Oryzias Phylogeny Sequence Homology, Amino Acid Transcription Factors / genetics Transcription Factors / physiology* Zebrafish Zebrafish Proteins / genetics Zebrafish Proteins / physiology*
IF 2.74
Human and Animal Cells BRF41(RCB0804)