| RRC ID |
78298
|
| Author |
Kwon J, Yoon HJ, Kim JH, Lee TS, Song IH, Lee HW, Kang MC, Park JH.
|
| Title |
Cetuximab inhibits cisplatin-induced activation of EGFR signaling in esophageal squamous cell carcinoma.
|
| Journal |
Oncol Rep
|
| Abstract |
A malignant esophageal cancer, squamous cell carcinoma is one of the most prevalent cancers. Despite the use of present surgical techniques combined with various treatment modalities, the overall 5-year survival rate remains at 15-34%. Epidermal growth factor receptor (EGFR) is the most well studied receptor in various cancers and EGFR overexpression is detected in 40% of esophageal squamous cell carcinomas (ESCCs) and ESCC cell lines. To examine the EGFR antibody combination effect, we used treatment with cisplatin and cetuximab in ESCC cell lines, TE-4 and TE-8. Combination of cetuximab and cisplatin resulted in a growth inhibition only in the EGFR overexpressed TE-8 cell line. Furthermore, we confirmed that cisplatin-induced EGFR activation was inhibited by cetuximab in TE-8 but not in TE-4 cells. Our data suggest that cetuximab combined with cisplatin exerts antitumorigenic effects in vitro and in vivo via suppression of EGF signaling, which can be applied toward targeted ESCC treatments.
|
| Volume |
32(3)
|
| Pages |
1188-92
|
| Published |
2014-9-1
|
| DOI |
10.3892/or.2014.3302
|
| PMID |
24993015
|
| MeSH |
Animals
Antibodies, Monoclonal, Humanized / administration & dosage*
Antibodies, Monoclonal, Humanized / pharmacology
Antineoplastic Agents / administration & dosage*
Antineoplastic Agents / pharmacology
Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
Carcinoma, Squamous Cell / drug therapy*
Carcinoma, Squamous Cell / metabolism
Cell Line, Tumor
Cell Proliferation / drug effects
Cetuximab
Cisplatin / administration & dosage*
Cisplatin / pharmacology
Drug Synergism
ErbB Receptors
Esophageal Neoplasms / drug therapy*
Esophageal Neoplasms / metabolism
Female
Humans
Mice
Mice, Inbred BALB C
Signal Transduction / drug effects*
Xenograft Model Antitumor Assays
|
| IF |
3.417
|
| Resource |
| Human and Animal Cells |
TE-1(RCB1894)
TE-4(RCB2097)
TE-5(RCB1949)
TE-6(RCB1950)
TE-8(RCB2098)
TE-9(RCB1988)
TE-10(RCB2099)
TE-11(RCB2100)
TE-14(RCB2101)
TE-15(RCB1951) |
