Reference - Detail
| RRC ID | 78329 |
|---|---|
| Author | Sofyana NT, Refli R, Takahashi M, Sakamoto K. |
| Title | Oxygen nanobubble water affects wound healing of fibroblast WI-38 cells. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
This study investigated the usefulness of oxygen nanobubble water (O2NBW) for wound repair by analyzing its effect on the wound-healing process in human lung fibroblasts (WI-38 cells). The WI-38 cells were treated with 0%, 50%, and 100% O2NBW. The cell viability, reactive oxygen species (ROS) production, and wound healing following treatment were determined to elucidate the effects of O2NBW. Our findings revealed that O2NBW had no cytotoxic effects on WI-38 cells, but instead increased cell numbers. The production of ROS was inhibited in the presence of O2NBW. Further, O2NBW induced migration and wound closure in WI-38 cells. In addition, the mRNA expression levels of antioxidant enzymes and wound-healing-related genes were evaluated. The results demonstrated that O2NBW enhanced the expression levels of all representative genes. In conclusion, our findings suggest that O2NBW could affect ROS production and wound healing in WI-38 cells and genes associated with the antioxidant system and wound healing. |
| Volume | 87(6) |
| Pages | 620-626 |
| Published | 2023-5-19 |
| DOI | 10.1093/bbb/zbad026 |
| PII | 7115317 |
| PMID | 37041088 |
| MeSH | Antioxidants* / metabolism Antioxidants* / pharmacology Cell Proliferation Fibroblasts Humans Oxygen* / metabolism Oxygen* / pharmacology Reactive Oxygen Species / metabolism Wound Healing |
| IF | 1.516 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | WI-38(RCB0702) |