RRC ID 78515
Author Matsuzaki F, Koizumi K, Hama C, Yoshioka T, Nabeshima Y.
Title Cloning of the Drosophila prospero gene and its expression in ganglion mother cells.
Journal Biochem Biophys Res Commun
Abstract The Drosophila central nervous system comprises an enormous diversity of neurons that are originated from neuronal stem cells, neuroblasts. They generate a specific series of ganglion mother cells, each of which is once cleaved into a pair of neurons. Among genes known to control neurogenesis, prospero (pros) was recently identified as a gene required for gene expression specifying properties of some identified neurons. Here we report that pros encodes a nuclear protein containing a homeodomain-like sequence. In neuronal lineages of the central nervous system, pros protein is specifically detected in ganglion mother cells, although their parental neuroblasts have begun expressing a significant level of pros transcripts, suggesting a post-transcriptional control of pros expression. Our results provoke that in neuronal cell differentiation ganglion mother cells might play a pivotal role associating with the pros function.
Volume 182(3)
Pages 1326-32
Published 1992-2-14
DOI 10.1016/0006-291x(92)91878-t
PII 0006-291X(92)91878-T
PMID 1540176
MeSH Amino Acid Sequence Animals Base Sequence Chromosome Deletion Cloning, Molecular Drosophila / genetics* Drosophila Proteins* Embryo, Nonmammalian / cytology Embryo, Nonmammalian / physiology Ganglia / physiology Gene Expression Genes* Immunohistochemistry Molecular Sequence Data Nerve Tissue Proteins / genetics* Neurons / physiology Nuclear Proteins / genetics* Peptides / chemical synthesis Peptides / immunology Restriction Mapping Sequence Homology, Nucleic Acid Transcription Factors* Transcription, Genetic
IF 2.985
Drosophila DGRC#119112 DGRC#119113 DGRC#119114 DGRC#119115