論文 - 詳細
| RRC ID | 78515 |
|---|---|
| 著者 | Matsuzaki F, Koizumi K, Hama C, Yoshioka T, Nabeshima Y. |
| タイトル | Cloning of the Drosophila prospero gene and its expression in ganglion mother cells. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
The Drosophila central nervous system comprises an enormous diversity of neurons that are originated from neuronal stem cells, neuroblasts. They generate a specific series of ganglion mother cells, each of which is once cleaved into a pair of neurons. Among genes known to control neurogenesis, prospero (pros) was recently identified as a gene required for gene expression specifying properties of some identified neurons. Here we report that pros encodes a nuclear protein containing a homeodomain-like sequence. In neuronal lineages of the central nervous system, pros protein is specifically detected in ganglion mother cells, although their parental neuroblasts have begun expressing a significant level of pros transcripts, suggesting a post-transcriptional control of pros expression. Our results provoke that in neuronal cell differentiation ganglion mother cells might play a pivotal role associating with the pros function. |
| 巻・号 | 182(3) |
| ページ | 1326-32 |
| 公開日 | 1992-2-14 |
| DOI | 10.1016/0006-291x(92)91878-t |
| PII | 0006-291X(92)91878-T |
| PMID | 1540176 |
| MeSH | Amino Acid Sequence Animals Base Sequence Chromosome Deletion Cloning, Molecular Drosophila / genetics* Drosophila Proteins* Embryo, Nonmammalian / cytology Embryo, Nonmammalian / physiology Ganglia / physiology Gene Expression Genes* Immunohistochemistry Molecular Sequence Data Nerve Tissue Proteins / genetics* Neurons / physiology Nuclear Proteins / genetics* Peptides / chemical synthesis Peptides / immunology Restriction Mapping Sequence Homology, Nucleic Acid Transcription Factors* Transcription, Genetic |
| IF | 2.985 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#119112 DGRC#119113 DGRC#119114 DGRC#119115 |