| RRC ID |
78515
|
| Author |
Matsuzaki F, Koizumi K, Hama C, Yoshioka T, Nabeshima Y.
|
| Title |
Cloning of the Drosophila prospero gene and its expression in ganglion mother cells.
|
| Journal |
Biochem Biophys Res Commun
|
| Abstract |
The Drosophila central nervous system comprises an enormous diversity of neurons that are originated from neuronal stem cells, neuroblasts. They generate a specific series of ganglion mother cells, each of which is once cleaved into a pair of neurons. Among genes known to control neurogenesis, prospero (pros) was recently identified as a gene required for gene expression specifying properties of some identified neurons. Here we report that pros encodes a nuclear protein containing a homeodomain-like sequence. In neuronal lineages of the central nervous system, pros protein is specifically detected in ganglion mother cells, although their parental neuroblasts have begun expressing a significant level of pros transcripts, suggesting a post-transcriptional control of pros expression. Our results provoke that in neuronal cell differentiation ganglion mother cells might play a pivotal role associating with the pros function.
|
| Volume |
182(3)
|
| Pages |
1326-32
|
| Published |
1992-2-14
|
| DOI |
10.1016/0006-291x(92)91878-t
|
| PII |
0006-291X(92)91878-T
|
| PMID |
1540176
|
| MeSH |
Amino Acid Sequence
Animals
Base Sequence
Chromosome Deletion
Cloning, Molecular
Drosophila / genetics*
Drosophila Proteins*
Embryo, Nonmammalian / cytology
Embryo, Nonmammalian / physiology
Ganglia / physiology
Gene Expression
Genes*
Immunohistochemistry
Molecular Sequence Data
Nerve Tissue Proteins / genetics*
Neurons / physiology
Nuclear Proteins / genetics*
Peptides / chemical synthesis
Peptides / immunology
Restriction Mapping
Sequence Homology, Nucleic Acid
Transcription Factors*
Transcription, Genetic
|
| IF |
2.985
|
| Resource |
| Drosophila |
DGRC#119112
DGRC#119113
DGRC#119114
DGRC#119115 |
