論文 - 詳細
| RRC ID | 79057 |
|---|---|
| 著者 | Nguyen TD, Miyatake Y, Yoshida T, Kawahara H, Hanayama R. |
| タイトル | Tumor-secreted proliferin-1 regulates adipogenesis and lipolysis in cachexia. |
| ジャーナル | Int J Cancer |
| Abstract |
Cancer-associated cachexia (CAC) is a common syndrome in cancer patients and is characterized by loss of body weight accompanied by the atrophy of fat and skeletal muscle. Metabolic changes are a critical factor in CAC; however, the mechanisms through which tumors inhibit adipogenesis and promote lipolysis are poorly understood. To clarify these mechanisms, we investigated adipogenesis-limiting factors released by tumors in a cell culture system. We identified proliferin-1 (PLF-1), a member of the growth hormone/prolactin gene family, as a key factor secreted from certain tumors that inhibited preadipocyte maturation and promoted the lipolysis of mature adipocytes. Importantly, mice transplanted with PLF-1-depleted tumor cells were protected from fat loss due to CAC. These data show that tumor-secreted PLF-1 plays an essential role in impaired adipogenesis and accelerated lipolysis and is a potential therapeutic target against CAC. |
| 巻・号 | 148(8) |
| ページ | 1982-1992 |
| 公開日 | 2021-4-15 |
| DOI | 10.1002/ijc.33418 |
| PMID | 33252827 |
| MeSH | Adipocytes / cytology Adipocytes / metabolism Adipogenesis / genetics* Animals Body Weight / genetics Cachexia / genetics* Cachexia / metabolism Cell Differentiation / genetics Cell Line, Tumor Cells, Cultured Gene Expression Regulation, Neoplastic Lipolysis / genetics* Mice Mice, Inbred C57BL Mice, Inbred ICR Mice, Knockout Neoplasms / genetics* Neoplasms / metabolism Neoplasms / pathology Prolactin / genetics* Prolactin / metabolism |
| IF | 5.145 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | FM3A(RCB0086) Ehrlich(RCB0142) EL4(RCB1641) |