| RRC ID |
79057
|
| 著者 |
Nguyen TD, Miyatake Y, Yoshida T, Kawahara H, Hanayama R.
|
| タイトル |
Tumor-secreted proliferin-1 regulates adipogenesis and lipolysis in cachexia.
|
| ジャーナル |
Int J Cancer
|
| Abstract |
Cancer-associated cachexia (CAC) is a common syndrome in cancer patients and is characterized by loss of body weight accompanied by the atrophy of fat and skeletal muscle. Metabolic changes are a critical factor in CAC; however, the mechanisms through which tumors inhibit adipogenesis and promote lipolysis are poorly understood. To clarify these mechanisms, we investigated adipogenesis-limiting factors released by tumors in a cell culture system. We identified proliferin-1 (PLF-1), a member of the growth hormone/prolactin gene family, as a key factor secreted from certain tumors that inhibited preadipocyte maturation and promoted the lipolysis of mature adipocytes. Importantly, mice transplanted with PLF-1-depleted tumor cells were protected from fat loss due to CAC. These data show that tumor-secreted PLF-1 plays an essential role in impaired adipogenesis and accelerated lipolysis and is a potential therapeutic target against CAC.
|
| 巻・号 |
148(8)
|
| ページ |
1982-1992
|
| 公開日 |
2021-4-15
|
| DOI |
10.1002/ijc.33418
|
| PMID |
33252827
|
| MeSH |
Adipocytes / cytology
Adipocytes / metabolism
Adipogenesis / genetics*
Animals
Body Weight / genetics
Cachexia / genetics*
Cachexia / metabolism
Cell Differentiation / genetics
Cell Line, Tumor
Cells, Cultured
Gene Expression Regulation, Neoplastic
Lipolysis / genetics*
Mice
Mice, Inbred C57BL
Mice, Inbred ICR
Mice, Knockout
Neoplasms / genetics*
Neoplasms / metabolism
Neoplasms / pathology
Prolactin / genetics*
Prolactin / metabolism
|
| リソース情報 |
| ヒト・動物細胞 |
FM3A(RCB0086)
Ehrlich(RCB0142)
EL4(RCB1641) |
