論文 - 詳細
| RRC ID | 80505 |
|---|---|
| 著者 | Kikuchi Y, Kawashima M, Iwatsuki M, Kimishima A, Tsutsumi H, Asami Y, Inahashi Y. |
| タイトル | Comprehensive analysis of biosynthetic gene clusters in bacteria and discovery of Tumebacillus as a potential producer of natural products. |
| ジャーナル | J Antibiot (Tokyo) |
| Abstract |
Limited microbial genera such as Streptomyces have served as sources of natural products (NPs), whereas most others have been less investigated. The vast accumulation of genomic data available in the NCBI database enables us to bioinformatically estimate the ability of other microbial groups to produce NPs. We analyzed 21,052 complete bacterial genome sequences using antiSMASH and compared the average numbers of biosynthetic gene clusters (BGCs) related to polyketides, non-ribosomal peptides, and/or terpenes biosynthesis at the genus level. Our bioinformatic analyses showed that Tumebacillus has 5-15 BGCs and is a promising NP producer. We searched for NPs from the culture broth of Tumebacillus permanentifrigoris JCM 14557T and found two novel compounds (tumebacin with anti-Bacillus activity and tumepyrazine) and identified two known compounds. Our results highlight the diversity of sources of NPs awaiting discovery. |
| 巻・号 | 76(6) |
| ページ | 316-323 |
| 公開日 | 2023-6-1 |
| DOI | 10.1038/s41429-023-00609-y |
| PII | 10.1038/s41429-023-00609-y |
| PMID | 36991235 |
| MeSH | Bacteria / genetics Biological Products* Computational Biology Genomics / methods Multigene Family |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 14557 |