論文 - 詳細
| RRC ID | 81359 |
|---|---|
| 著者 | Riley E, Maymi V, Pawlyszyn S, Yu L, Zhdanova IV. |
| タイトル | Prenatal cocaine exposure disrupts the dopaminergic system and its postnatal responses to cocaine. |
| ジャーナル | Genes Brain Behav |
| Abstract |
Impaired attention is the hallmark consequence of prenatal cocaine exposure (PCE), affecting brain development, learning, memory and social adaptation starting at an early age. To date, little is known about the brain structures and neurochemical processes involved in this effect. Through focusing on the visual system and employing zebrafish as a model, we show that PCE reduces expression of dopamine receptor Drd1, with levels reduced in the optic tectum and other brain regions, but not the telencephalon. Organism-wide, PCE results in a 1.7-fold reduction in the expression of the dopamine transporter (dat), at baseline. Acute cocaine administration leads to a 2-fold reduction in dat in drug-naive larvae but not PCE fish. PCE sensitizes animals to an anxiogenic-like behavioral effect of acute cocaine, bottom-dwelling, while loss of DAT due to genetic knockout (DATKO) leads to bottom-dwelling behavior at baseline. Neuronal calcium responses to visual stimuli in both PCE and DATKO fish show tolerance to acute cocaine in the principal regions of visual attention, the telencephalon and optic tectum. The zebrafish model can provide a sensitive assay by which to elucidate the molecular mechanisms and brain region-specific consequences of PCE, and facilitate the search for effective therapeutic solutions. |
| 巻・号 | 17(4) |
| ページ | e12436 |
| 公開日 | 2018-4-1 |
| DOI | 10.1111/gbb.12436 |
| PMID | 29105298 |
| MeSH | Animals Brain / drug effects Brain / metabolism Cocaine / administration & dosage Cocaine / toxicity* Dopamine / metabolism Dopamine Plasma Membrane Transport Proteins / metabolism Dopamine Uptake Inhibitors / administration & dosage Dopaminergic Neurons / drug effects* Dopaminergic Neurons / metabolism Female Larva / drug effects Male Neurons / metabolism Receptors, Dopamine D1 / metabolism* Zebrafish |
| IF | 3.397 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | UAS:GCaMPHS |