論文 - 詳細
| RRC ID | 81500 |
|---|---|
| 著者 | Ghosh S, Chakraborti S, Devi D, Sahu R, Mandal S, Mandal L. |
| タイトル | A conserved nutrient responsive axis mediates autophagic degradation of miRNA-mRNA hybrids in blood cell progenitors. |
| ジャーナル | Nucleic Acids Res |
| Abstract |
In animals, microRNAs are amongst the primary non-coding RNAs involved in regulating the gene expression of a cell. Most mRNAs in a cell are targeted by one or many miRNAs. Although several mechanisms can be attributed to the degradation of miRNA and mRNA within a cell, but the involvement of autophagy in the clearance of miRNA and its target mRNA is not known. We discover a leucine-responsive axis in blood cell progenitors that can mediate an autophagy-directed degradation of miRNA-bound mRNA in Drosophila melanogaster and Homo sapiens. This previously unknown miRNA clearance axis is activated upon amino acid deprivation that can traffic miRNA-mRNA-loaded Argonaute for autophagic degradation in a p62-dependent manner. Thus, our research not only reports a novel axis that can address the turnover of a catalytically active miRISC but also elucidates a slicer-independent mechanism through which autophagy can selectively initiate the clearance of target mRNA. |
| 巻・号 | 52(1) |
| ページ | 385-403 |
| 公開日 | 2024-1-11 |
| DOI | 10.1093/nar/gkad1047 |
| PII | 7442544 |
| PMID | 37994707 |
| PMC | PMC10783512 |
| MeSH | Animals Argonaute Proteins / genetics Argonaute Proteins / metabolism Autophagy / genetics Blood Cells Drosophila melanogaster / genetics Drosophila melanogaster / metabolism MicroRNAs* / genetics MicroRNAs* / metabolism RNA, Messenger / genetics RNA, Messenger / metabolism |
| IF | 11.502 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 50 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#105442 |