Reference - Detail
| RRC ID | 81718 |
|---|---|
| Author | Masano Y, Saegusa C, Ishikawa M, Matsunaga T, Okano H, Fujioka M. |
| Title | Generation of an induced pluripotent stem cell line (KEIUi008-A) from a hearing loss patient with an A1555G mutation in mitochondrial DNA. |
| Journal | Stem Cell Res |
| Abstract |
We report the establishment of a human induced pluripotent stem cell (iPSC) line from a 54-year-old male patient with an A1555G mutation in the mitochondrial 12S ribosomal RNA gene (MTRNR1), associated with sensorineural hearing loss. The established iPSC line expressed stemness markers or undifferentiated state markers. We also demonstrated the capacity of the cells to differentiate into the three germ layers, suggesting its pluripotency and utility in the pathological study of sensorineural hearing loss and drug screening for ear disorders. |
| Volume | 78 |
| Pages | 103452 |
| Published | 2024-8-1 |
| DOI | 10.1016/j.scr.2024.103452 |
| PII | S1873-5061(24)00150-8 |
| PMID | 38815527 |
| MeSH | Cell Differentiation Cell Line DNA, Mitochondrial* / genetics Hearing Loss / genetics Hearing Loss / pathology Hearing Loss, Sensorineural / genetics Hearing Loss, Sensorineural / pathology Humans Induced Pluripotent Stem Cells* / metabolism Male Middle Aged Mutation* RNA, Ribosomal / genetics |
| IF | 4.495 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | 201B7(HPS0063) |