論文 - 詳細
| RRC ID | 82863 |
|---|---|
| 著者 | Marsden KC, Granato M. |
| タイトル | In Vivo Ca(2+) Imaging Reveals that Decreased Dendritic Excitability Drives Startle Habituation. |
| ジャーナル | Cell Rep |
| Abstract |
Exposure to repetitive startling stimuli induces habitation, a simple form of learning. Despite its simplicity, the precise cellular mechanisms by which repeated stimulation converts a robust behavioral response to behavioral indifference are unclear. Here, we use head-restrained zebrafish larvae to monitor subcellular Ca(2+) dynamics in Mauthner neurons, the startle command neurons, during startle habituation in vivo. Using the Ca(2+) reporter GCaMP6s, we find that the amplitude of Ca(2+) signals in the lateral dendrite of the Mauthner neuron determines startle probability and that depression of this dendritic activity rather than downstream inhibition mediates glycine and N-methyl-D-aspartate (NMDA)-receptor-dependent short-term habituation. Combined, our results suggest a model for habituation learning in which increased inhibitory drive from feedforward inhibitory neurons combined with decreased excitatory input from auditory afferents decreases dendritic and Mauthner neuron excitability. |
| 巻・号 | 13(9) |
| ページ | 1733-40 |
| 公開日 | 2015-12-1 |
| DOI | 10.1016/j.celrep.2015.10.060 |
| PII | S2211-1247(15)01249-8 |
| PMID | 26655893 |
| PMC | PMC4680997 |
| MeSH | Animals Calcium / metabolism* Calcium Signaling / drug effects Dendrites / metabolism* Dizocilpine Maleate / pharmacology Larva / metabolism Neuronal Calcium-Sensor Proteins / metabolism Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors Receptors, N-Methyl-D-Aspartate / metabolism Reflex, Startle / drug effects Strychnine / pharmacology Zebrafish / growth & development Zebrafish / metabolism |
| IF | 8.109 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | hspGFF62A |