論文 - 詳細
| RRC ID | 83333 |
|---|---|
| 著者 | Chen YY, Liu YF, Liu YD, Deng XH, Zhou J. |
| タイトル | IRF7 suppresses hematopoietic regeneration under stress via CXCR4. |
| ジャーナル | Stem Cells |
| Abstract |
Hematopoietic stem cells (HSCs) maintain quiescence under steady state; however, they are compelled to proliferate and expand to replenish the blood system under stress. The molecular basis underlying stress hematopoiesis remains to be fully understood. In this study, we reported that IRF7 represents an important regulator of stress hematopoiesis. Interferon regulatory factor 7 (IRF7) was dispensable for normal hematopoiesis, whereas its deficiency significantly enhanced hematopoietic stem and progenitor cells (HSPCs) regeneration and improved long-term repopulation of HSCs under stress. Mechanistic studies showed that CXCR4 was identified as a downstream target of IRF7. Overexpression of CXCR4 abrogated the enhanced proliferation and regeneration of IRF7-deficient HSPCs under stress. Similar results were obtained in HSCs from human umbilical cord blood. These observations demonstrated that IRF7 plays an important role in hematopoietic regeneration under stress. |
| 巻・号 | 39(2) |
| ページ | 183-195 |
| 公開日 | 2021-2-1 |
| DOI | 10.1002/stem.3308 |
| PMID | 33252829 |
| MeSH | Animals Cells, Cultured Cord Blood Stem Cell Transplantation / methods* Fetal Blood / metabolism Fetal Blood / transplantation Hematopoiesis / physiology* Humans Interferon Regulatory Factor-7 / antagonists & inhibitors Interferon Regulatory Factor-7 / genetics Interferon Regulatory Factor-7 / metabolism* Mice Mice, Inbred C57BL Mice, Knockout Oxidative Stress / physiology* Receptors, CXCR4 / genetics Receptors, CXCR4 / metabolism* |
| IF | 6.022 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC01420 |