Reference - Detail
| RRC ID | 83504 |
|---|---|
| Author | Morozumi Y, Hayashi Y, Chu CM, Sofyantoro F, Akikusa Y, Fukuda T, Shiozaki K. |
| Title | Fission yeast Pib2 localizes to vacuolar membranes and regulates TOR complex 1 through evolutionarily conserved domains. |
| Journal | FEBS Lett |
| Abstract |
TOR complex 1 (TORC1) is a multi-protein kinase complex that coordinates cellular growth with environmental cues. Recent studies have identified Pib2 as a critical activator of TORC1 in budding yeast. Here, we show that loss of Pib2 causes severe growth defects in fission yeast cells, particularly when basal TORC1 activity is diminished by hypomorphic mutations in tor2, the gene encoding the catalytic subunit of TORC1. Consistently, TORC1 activity is significantly compromised in the tor2 hypomorphic mutants lacking Pib2. Moreover, as in budding yeast, fission yeast Pib2 localizes to vacuolar membranes via its FYVE domain, with its tail motif indispensable for TORC1 activation. These results strongly suggest that Pib2-mediated positive regulation of TORC1 is evolutionarily conserved between the two yeast species. |
| Volume | 598(23) |
| Pages | 2886-2896 |
| Published | 2024-12-1 |
| DOI | 10.1002/1873-3468.14980 |
| PMID | 39010328 |
| MeSH | Conserved Sequence Evolution, Molecular Intracellular Membranes* / metabolism Mechanistic Target of Rapamycin Complex 1* / genetics Mechanistic Target of Rapamycin Complex 1* / metabolism Mutation Protein Domains Schizosaccharomyces* / genetics Schizosaccharomyces* / metabolism Schizosaccharomyces pombe Proteins* / genetics Schizosaccharomyces pombe Proteins* / metabolism Vacuoles* / metabolism |
| IF | 3.057 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | Peer-review(Publons) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Yeast | |