RRC ID |
839
|
著者 |
Nishimura R, Hayashi M, Wu GJ, Kouchi H, Imaizumi-Anraku H, Murakami Y, Kawasaki S, Akao S, Ohmori M, Nagasawa M, Harada K, Kawaguchi M.
|
タイトル |
HAR1 mediates systemic regulation of symbiotic organ development.
|
ジャーナル |
Nature
|
Abstract |
Symbiotic root nodules are beneficial to leguminous host plants; however, excessive nodulation damages the host because it interferes with the distribution of nutrients in the plant. To keep a steady balance, the nodulation programme is regulated systemically in leguminous hosts. Leguminous mutants that have lost this ability display a hypernodulating phenotype. Through the use of reciprocal and self-grafting studies using Lotus japonicus hypernodulating mutants, har1 (also known as sym78), we show that the shoot genotype is responsible for the negative regulation of nodule development. A map-based cloning strategy revealed that HAR1 encodes a protein with a relative molecular mass of 108,000, which contains 21 leucine-rich repeats, a single transmembrane domain and serine/threonine kinase domains. The har1 mutant phenotype was rescued by transfection of the HAR1 gene. In a comparison of Arabidopsis receptor-like kinases, HAR1 showed the highest level of similarity with CLAVATA1 (CLV1). CLV1 negatively regulates formation of the shoot and floral meristems through cell-cell communication involving the CLV3 peptide. Identification of hypernodulation genes thus indicates that genes in leguminous plants bearing a close resemblance to CLV1 regulate nodule development systemically, by means of organ-organ communication.
|
巻・号 |
420(6914)
|
ページ |
426-9
|
公開日 |
2002-11-28
|
DOI |
10.1038/nature01231
|
PII |
nature01231
|
PMID |
12442172
|
MeSH |
Arabidopsis Proteins / chemistry
Arabidopsis Proteins / genetics
Chromosome Mapping
Cloning, Molecular
DNA, Plant / analysis
DNA, Plant / genetics
Genes, Plant / genetics
Genetic Complementation Test
Lotus / enzymology*
Lotus / genetics
Lotus / growth & development*
Lotus / metabolism
Molecular Sequence Data
Mutation / genetics
Nitrogen Fixation*
Plant Roots / enzymology
Plant Roots / genetics
Plant Roots / growth & development
Plant Roots / metabolism
Plant Shoots / enzymology
Plant Shoots / genetics
Plant Shoots / metabolism
Protein Serine-Threonine Kinases / chemistry
Protein Serine-Threonine Kinases / genetics
Protein Serine-Threonine Kinases / metabolism*
RNA, Plant / analysis
RNA, Plant / genetics
Receptor Protein-Tyrosine Kinases / chemistry
Receptor Protein-Tyrosine Kinases / genetics
Signal Transduction
Soybeans / chemistry
Soybeans / genetics
Symbiosis*
Transplants
|
IF |
42.779
|
引用数 |
355
|
WOS 分野
|
PLANT SCIENCES
|
リソース情報 |
ミヤコグサ・ダイズ |
Gifu B-129
Miyakojima MG-20 |