論文 - 詳細
| RRC ID | 84130 |
|---|---|
| 著者 | Liu C, Dernburg AF. |
| タイトル | Chemically induced proximity reveals a Piezo-dependent meiotic checkpoint at the oocyte nuclear envelope. |
| ジャーナル | Science |
| Abstract |
Sexual reproduction relies on robust quality control during meiosis. Assembly of the synaptonemal complex between homologous chromosomes (synapsis) regulates meiotic recombination and is crucial for accurate chromosome segregation in most eukaryotes. Synapsis defects can trigger cell cycle delays and, in some cases, apoptosis. We developed and deployed a chemically induced proximity system to identify key elements of this quality control pathway in Caenorhabditis elegans. Persistence of the polo-like kinase PLK-2 at pairing centers-specialized chromosome regions that interact with the nuclear envelope-induced apoptosis of oocytes in response to phosphorylation and destabilization of the nuclear lamina. Unexpectedly, the Piezo1/PEZO-1 channel localized to the nuclear envelope and was required to transduce this signal to promote apoptosis in maturing oocytes. |
| 巻・号 | 386(6724) |
| ページ | eadm7969 |
| 公開日 | 2024-11-22 |
| DOI | 10.1126/science.adm7969 |
| PMID | 39571011 |
| MeSH | Animals Apoptosis* Caenorhabditis elegans* / genetics Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Chromosome Pairing Female Ion Channels* / genetics Ion Channels* / metabolism Meiosis* Nuclear Envelope* / metabolism Oocytes* / metabolism Phosphorylation Polo-like Kinases Protein Serine-Threonine Kinases* / genetics Protein Serine-Threonine Kinases* / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 83 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm9715 tmIs1219 tmC20 tm1458 |